Asymmetric Cell Division of Stem and Progenitor Cells During Homeostasis and Cancer

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2013 Jun 18

PMID 23771628

Citations 75

Authors

Sandra Gomez-Lopez

Robin G Lerner

Claudia Petritsch

Affiliations

Soon will be listed here.

Abstract

Stem and progenitor cells are characterized by their ability to self-renew and produce differentiated progeny. A fine balance between these processes is achieved through controlled asymmetric divisions and is necessary to generate cellular diversity during development and to maintain adult tissue homeostasis. Disruption of this balance may result in premature depletion of the stem/progenitor cell pool, or abnormal growth. In many tissues, including the brain, dysregulated asymmetric divisions are associated with cancer. Whether there is a causal relationship between asymmetric cell division defects and cancer initiation is as yet not known. Here, we review the cellular and molecular mechanisms that regulate asymmetric cell divisions in the neural lineage and discuss the potential connections between this regulatory machinery and cancer.

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References

Sato T, Okumura F, Kano S, Kondo T, Ariga T, Hatakeyama S . TRIM32 promotes neural differentiation through retinoic acid receptor-mediated transcription. J Cell Sci. 2011; 124(Pt 20):3492-502. DOI: 10.1242/jcs.088799. View

Qian X, Shen Q, Goderie S, He W, Capela A, Davis A . Timing of CNS cell generation: a programmed sequence of neuron and glial cell production from isolated murine cortical stem cells. Neuron. 2000; 28(1):69-80. DOI: 10.1016/s0896-6273(00)00086-6. View

Bowman S, Neumuller R, Novatchkova M, Du Q, Knoblich J . The Drosophila NuMA Homolog Mud regulates spindle orientation in asymmetric cell division. Dev Cell. 2006; 10(6):731-42. DOI: 10.1016/j.devcel.2006.05.005. View

Zhu X, Hill R, Dietrich D, Komitova M, Suzuki R, Nishiyama A . Age-dependent fate and lineage restriction of single NG2 cells. Development. 2011; 138(4):745-53. PMC: 3026417. DOI: 10.1242/dev.047951. View

Regala R, Weems C, Jamieson L, Copland J, Thompson E, Fields A . Atypical protein kinase Ciota plays a critical role in human lung cancer cell growth and tumorigenicity. J Biol Chem. 2005; 280(35):31109-15. DOI: 10.1074/jbc.M505402200. View

Okabe M, Imai T, Kurusu M, Hiromi Y, Okano H . Translational repression determines a neuronal potential in Drosophila asymmetric cell division. Nature. 2001; 411(6833):94-8. DOI: 10.1038/35075094. View

Kelly J, Blough M, Stechishin O, Chan J, Beauchamp D, Perizzolo M . Oligodendroglioma cell lines containing t(1;19)(q10;p10). Neuro Oncol. 2010; 12(7):745-55. PMC: 2940664. DOI: 10.1093/neuonc/noq031. View

Sakai D, Dixon J, Dixon M, Trainor P . Mammalian neurogenesis requires Treacle-Plk1 for precise control of spindle orientation, mitotic progression, and maintenance of neural progenitor cells. PLoS Genet. 2012; 8(3):e1002566. PMC: 3315461. DOI: 10.1371/journal.pgen.1002566. View

Barry D, McDermott K . Differentiation of radial glia from radial precursor cells and transformation into astrocytes in the developing rat spinal cord. Glia. 2005; 50(3):187-97. DOI: 10.1002/glia.20166. View

10.

Bao S, Wu Q, McLendon R, Hao Y, Shi Q, Hjelmeland A . Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature. 2006; 444(7120):756-60. DOI: 10.1038/nature05236. View

11.

Kusek G, Campbell M, Doyle F, Tenenbaum S, Kiebler M, Temple S . Asymmetric segregation of the double-stranded RNA binding protein Staufen2 during mammalian neural stem cell divisions promotes lineage progression. Cell Stem Cell. 2012; 11(4):505-16. PMC: 3466335. DOI: 10.1016/j.stem.2012.06.006. View

12.

Friedmann-Morvinski D, Bushong E, Ke E, Soda Y, Marumoto T, Singer O . Dedifferentiation of neurons and astrocytes by oncogenes can induce gliomas in mice. Science. 2012; 338(6110):1080-4. PMC: 3595315. DOI: 10.1126/science.1226929. View

13.

Gal J, Morozov Y, Ayoub A, Chatterjee M, Rakic P, Haydar T . Molecular and morphological heterogeneity of neural precursors in the mouse neocortical proliferative zones. J Neurosci. 2006; 26(3):1045-56. PMC: 3249619. DOI: 10.1523/JNEUROSCI.4499-05.2006. View

14.

Chen J, Li Y, Yu T, McKay R, Burns D, Kernie S . A restricted cell population propagates glioblastoma growth after chemotherapy. Nature. 2012; 488(7412):522-6. PMC: 3427400. DOI: 10.1038/nature11287. View

15.

Qian X, Goderie S, Shen Q, Stern J, Temple S . Intrinsic programs of patterned cell lineages in isolated vertebrate CNS ventricular zone cells. Development. 1998; 125(16):3143-52. DOI: 10.1242/dev.125.16.3143. View

16.

Muto J, Imai T, Ogawa D, Nishimoto Y, Okada Y, Mabuchi Y . RNA-binding protein Musashi1 modulates glioma cell growth through the post-transcriptional regulation of Notch and PI3 kinase/Akt signaling pathways. PLoS One. 2012; 7(3):e33431. PMC: 3299785. DOI: 10.1371/journal.pone.0033431. View

17.

Knecht R, Elez R, Oechler M, Solbach C, von Ilberg C, Strebhardt K . Prognostic significance of polo-like kinase (PLK) expression in squamous cell carcinomas of the head and neck. Cancer Res. 1999; 59(12):2794-7. View

18.

McCaffrey L, Macara I . The Par3/aPKC interaction is essential for end bud remodeling and progenitor differentiation during mammary gland morphogenesis. Genes Dev. 2009; 23(12):1450-60. PMC: 2701573. DOI: 10.1101/gad.1795909. View

19.

Wodarz A, Ramrath A, Grimm A, Knust E . Drosophila atypical protein kinase C associates with Bazooka and controls polarity of epithelia and neuroblasts. J Cell Biol. 2000; 150(6):1361-74. PMC: 2150710. DOI: 10.1083/jcb.150.6.1361. View

20.

Yamashita Y, Yuan H, Cheng J, Hunt A . Polarity in stem cell division: asymmetric stem cell division in tissue homeostasis. Cold Spring Harb Perspect Biol. 2010; 2(1):a001313. PMC: 2827902. DOI: 10.1101/cshperspect.a001313. View