Investigating the Attenuating Effects of Metformin-loaded Selenium Nanoparticles Coupled with L. Flower Extract on CaOx Deposition in Male Sprague Dawley Rat Kidneys Via Regulating MAPK Signaling Pathway

Overview

Journal Regen Ther

Date 2024 Dec 18

PMID 39691916

Authors

Jian Kang

Yanqing Tong

Affiliations

Soon will be listed here.

Abstract

Kidney stones are a foremost clinical concern in urology with CaOx crystals accounting for roughly 80% of these renal formations. This research endeavor seeks to ascertain the protective effects of Metformin-encapsulated selenium nanoparticles (M@Se NPs), combined with a 55% hydroethanolic flower extract from () in countering the formation of kidney stones in Male Sprague Dawley rats. The particle's diameter was measured to be 39 nm and 13.8 nm from DLS and HR-TEM analysis. Rat groups administered with the -M@Se NPs (1:1.5:1) exhibited reduced renal stone formation in urine and serum analysis compared to the negative control group. Histological evaluations of kidney samples using H&E, and MTS staining indicated a subdued presence of ECM deposition in contrast to other rat groups. Conclusively, the protective mechanism of -M@Se NPs against CaOx stone damage can be confidently attributed to the obstruction of the MAPK signaling pathway.

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