Correlation Between 25-hydroxyvitamin D and Severe Headache or Migraine: Evidence from NHANES Database

Overview

Journal Food Nutr Res

Specialty Nutritional Sciences

Date 2024 Dec 18

PMID 39691689

Authors

Xiaolei Zhang

Jiangwen Wu

Ting Wu

Liwen Guo

Ruiping Zhang

Xin Jin

Affiliations

Soon will be listed here.

Abstract

Objective: This study was formulated with the objective of elucidating the correlation between 25-hydroxyvitamin D (25(OH)D) and the occurrence of severe headache or migraine, employing a cross-sectional analytical approach.

Methods: A cross-sectional survey was conducted over two cycles involving 7,661 participants, utilizing data from the National Health and Nutrition Examination Survey (NHANES) conducted between 2001 and 2004. A weighted logistic regression method was employed to construct a relationship model between the two variables. Subgroup analysis, adjusting for confounding factors, was performed through stratified analysis to explore the association between 25(OH)D and severe headaches or migraines. Finally, a restricted cubic spline regression (RCS) was utilized to investigate the non-linear relationship between the variables.

Results: A total of 7,661 participants were included in this study, with an overall prevalence of severe headaches or migraines of 1,576/7,661 (22.3%). The results from all models consistently indicated a significant negative correlation between serum 25(OH)D levels and the risk of severe headaches or migraines ( < 0.05). Stratified analysis revealed that in the female population (odds ratios [OR]: 0.995, 95% CI: 0.991-0.998, = 0.001), never smokers (OR: 0.991, 95% CI: 0.985-0.997, = 0.003), and non-drinkers (OR: 0.993, 95% CI: 0.987-0.999, = 0.022), the risk of severe headaches or migraines decreased with increasing serum 25(OH)D concentrations. RCS results demonstrated a linear relationship between serum 25(OH)D levels and the risk of severe headaches or migraines.

Conclusion: We discovered a negative correlation between serum 25(OH)D levels and the prevalence of severe headaches or migraines, particularly in females, non-smokers, and non-hypertensive individuals. Further clinical research is necessary to confirm these findings, establish causality, and explore potential preventive and therapeutic mechanisms for migraines.

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