Vortex-Mixing Microfluidic Fabrication of Micafungin-Loaded Magnetite-Salicylic Acid-Silica Nanocomposite with Sustained-Release Capacity

Overview

Journal Materials (Basel)

Publisher MDPI

Date 2024 Dec 17

PMID 39685251

Authors

Doina-Antonia Mercan

Adelina-Gabriela Niculescu

Alexandra Catalina Birca

Diana-Elena Cristea

Alina Morosan

Dana-Ionela Tudorache

Bogdan Purcareanu

Bogdan Stefan Vasile

Dana Radu

Mihai Alexandru Grigoroscuta

Tony Hadibarata

Dan Eduard Mihaiescu

Alexandru Mihai Grumezescu

Affiliations

Soon will be listed here.

Abstract

Iron oxide nanoparticles were synthesized using a vortex microfluidic system and subsequently functionalized with a primary shell of salicylic acid, recognized for its ability to increase the stability and biocompatibility of coated materials. In the second stage, the vortex platform was placed in a magnetic field to facilitate the growth and development of a porous silica shell. The selected drug for this study was micafungin, an antifungal agent well regarded for its effectiveness in combating fungal infections and identified as a priority compound by the World Health Organization (WHO). The resulting nanocomposite system was characterized using various techniques, including Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), transmission electron microscopy (TEM), dynamic light scattering (DLS), Brunauer-Emmett-Teller (BET) analysis, UV-Vis spectroscopy, and Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS). The synthesis method produced nanoparticles with dimensions of 5-7 nm, highlighting the advantages of the chosen approach. A desorption profile was established using a continuous-flow, UV-Vis analysis system, indicating that the bioactive compound was released slowly; after two hours, approximately 50% of the loaded micafungin was detected in the release medium. Furthermore, the results obtained from the FT-ICR MS analysis provided molecular-level confirmation, thereby supporting the release mechanism of micafungin from the nanosystem.

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