Bioplatform Fabrication Approaches Affecting Chitosan-Based Interpolymer Complex Properties and Performance As Wound Dressings

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2020 Jan 16

PMID 31935794

Citations 7

Authors

Hillary Mndlovu

Lisa C du Toit

Pradeep Kumar

Yahya E Choonara

Thashree Marimuthu

Pierre P D Kondiah

Viness Pillay

Affiliations

Soon will be listed here.

Abstract

Chitosan can form interpolymer complexes (IPCs) with anionic polymers to form biomedical platforms (BMPs) for wound dressing/healing applications. This has resulted in its application in various BMPs such as gauze, nano/microparticles, hydrogels, scaffolds, and films. Notably, wound healing has been highlighted as a noteworthy application due to the remarkable physical, chemical, and mechanical properties enabled though the interaction of these polyelectrolytes. The interaction of chitosan and anionic polymers can improve the properties and performance of BMPs. To this end, the approaches employed in fabricating wound dressings was evaluated for their effect on the property-performance factors contributing to BMP suitability in wound dressing. The use of chitosan in wound dressing applications has had much attention due to its compatible biological properties. Recent advancement includes the control of the degree of crosslinking and incorporation of bioactives in an attempt to enhance the physicochemical and physicomechanical properties of wound dressing BMPs. A critical issue with polyelectrolyte-based BMPs is that their effective translation to wound dressing platforms has yet to be realised due to the unmet challenges faced when mimicking the complex and dynamic wound environment. Novel BMPs stemming from the IPCs of chitosan are discussed in this review to offer new insight into the tailoring of physical, chemical, and mechanical properties via fabrication approaches to develop effective wound dressing candidates. These BMPs may pave the way to new therapeutic developments for improved patient outcomes.

Citing Articles

Recent Advancements in Chitosan-Based Biomaterials for Wound Healing.

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The Promoting Effect of Animal Bioactive Proteins and Peptide Components on Wound Healing: A Review.

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Multiple-Layer Chitosan-Based Patches Medicated With LTX-109 Antimicrobial Peptide for Modulated Local Therapy in the Management of Chronic Wounds.

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Natural and Synthetic Polymeric Biomaterials for Application in Wound Management.

Prete S, Dattilo M, Patitucci F, Pezzi G, Parisi O, Puoci F J Funct Biomater. 2023; 14(9).

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Amikacin-Loaded Chitosan Hydrogel Film Cross-Linked with Folic Acid for Wound Healing Application.

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