Visualization of Stress Fiber Formation Induced by Photodynamic Therapy with Porphylipoprotein
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Abstract
We investigated stress fiber formation induced by photodynamic therapy (PDT) with porphylipoprotein (PLP) by observing actin filaments by super-resolution confocal microscopy and measuring the cellular elastic modulus by atomic force microscopy. We identified different intracellular mechanisms of stress fiber formation between RGM1 epithelial cells, which were derived from rat gastric mucosa, and RGK1 cells, which were cancer-like mutants of RGM1. Our findings show that when PLP is used as a photosensitizer in PDT, it selectively induces necrosis in tumors with minimal impact on the surrounding normal tissues, as it is less likely to cause blood flow obstruction.
References
1.
Shimokawa O, Matsui H, Nagano Y, Kaneko T, Shibahara T, Nakahara A
. Neoplastic transformation and induction of H+,K+ -adenosine triphosphatase by N-methyl-N'-nitro-N-nitrosoguanidine in the gastric epithelial RGM-1 cell line. In Vitro Cell Dev Biol Anim. 2007; 44(1-2):26-30.
DOI: 10.1007/s11626-007-9067-8.
View
2.
Cheng W, Nie J, Xu L, Liang C, Peng Y, Liu G
. pH-Sensitive Delivery Vehicle Based on Folic Acid-Conjugated Polydopamine-Modified Mesoporous Silica Nanoparticles for Targeted Cancer Therapy. ACS Appl Mater Interfaces. 2017; 9(22):18462-18473.
DOI: 10.1021/acsami.7b02457.
View
3.
Sanz-Moreno V, Marshall C
. The plasticity of cytoskeletal dynamics underlying neoplastic cell migration. Curr Opin Cell Biol. 2010; 22(5):690-6.
DOI: 10.1016/j.ceb.2010.08.020.
View
4.
Kurokawa H, Taninaka A, Shigekawa H, Matsui H
. Dabigatran Etexilate Induces Cytotoxicity in Rat Gastric Epithelial Cell Line via Mitochondrial Reactive Oxygen Species Production. Cells. 2021; 10(10).
PMC: 8533938.
DOI: 10.3390/cells10102508.
View
5.
Blocker A, Griffiths G, Olivo J, Hyman A, Severin F
. A role for microtubule dynamics in phagosome movement. J Cell Sci. 1998; 111 ( Pt 3):303-12.
DOI: 10.1242/jcs.111.3.303.
View