» Articles » PMID: 39679667

Enhanced Multistress Tolerance of with the Sugar Transporter-like Protein Stl1 Mutation in the Presence of Glycerol

Overview
Specialty Microbiology
Date 2024 Dec 16
PMID 39679667
Authors
Affiliations
Soon will be listed here.
Abstract

Importance: Stl1 exhibits improved strain tolerance to multistress when adding glycerol, may enhance glycerol molecular binding, and can make a significant increase in intracellular glycerol content. It can reduce reactive oxygen species levels and increase ergosterol content. This paper provides novel insights and methods to get robust industrial microorganisms.

References
1.
Rodrigues C, Pires D, Ascher D . DynaMut: predicting the impact of mutations on protein conformation, flexibility and stability. Nucleic Acids Res. 2018; 46(W1):W350-W355. PMC: 6031064. DOI: 10.1093/nar/gky300. View

2.
Song J, Park J, Kang C, Cho H, Yang D, Lee S . Introduction of a bacterial acetyl-CoA synthesis pathway improves lactic acid production in Saccharomyces cerevisiae. Metab Eng. 2015; 35:38-45. DOI: 10.1016/j.ymben.2015.09.006. View

3.
Sargsyan K, Grauffel C, Lim C . How Molecular Size Impacts RMSD Applications in Molecular Dynamics Simulations. J Chem Theory Comput. 2017; 13(4):1518-1524. DOI: 10.1021/acs.jctc.7b00028. View

4.
Sone M, Navanopparatsakul K, Takahashi S, Furusawa C, Hirasawa T . Loss of function of Hog1 improves glycerol assimilation in Saccharomyces cerevisiae. World J Microbiol Biotechnol. 2023; 39(10):255. PMC: 10359374. DOI: 10.1007/s11274-023-03696-z. View

5.
Yang H, Zhang C, Lai N, Huang B, Fei P, Ding D . Efficient isopropanol biosynthesis by engineered Escherichia coli using biologically produced acetate from syngas fermentation. Bioresour Technol. 2019; 296:122337. DOI: 10.1016/j.biortech.2019.122337. View