Linkage and Recombination Between Fragile X-linked Mental Retardation and the Factor IX Gene

Overview

Journal Hum Genet

Specialty Genetics

Date 1985 Jan 1

PMID 3967889

Citations 14

Authors

S T Warren

T W Glover

R L Davidson

P Jagadeeswaran

Affiliations

Soon will be listed here.

Abstract

Linkage analysis on a family with fragile X-linked mental retardation was performed using a Taq 1 restriction fragment length polymorphism detected by a cloned human coagulation factor IX cDNA. Two affected brothers in this sibship were found to have different factor IX RFLP alleles, indicating a recombinational event occurred between the two genes. Our data therefore indicate that the gene responsible for fragile X-linked mental retardation is not as tightly linked to the factor IX gene as the previously published data may suggest.

Citing Articles

Two sisters with a distal deletion at the Xq26/Xq27 interface: DNA studies indicate that the gene locus for factor IX is present.

Schwartz C, Fitch N, Phelan M, RICHER C, Stevenson R Hum Genet. 1987; 76(1):54-7.

PMID: 3471705 DOI: 10.1007/BF00283050.

Analysis of linkage relationships between genetic markers around the fragile X locus with special reference to the daughters of normal transmitting males.

Winter R, Pembrey M Hum Genet. 1986; 74(1):93-7.

PMID: 3463533 DOI: 10.1007/BF00278793.

Linkage analysis using multiple DNA polymorphic markers in normal families and in families with fragile X syndrome.

Thibodeau S, Dorkins H, Faulk K, Berry R, Smith A, Hagerman R Hum Genet. 1988; 79(3):219-27.

PMID: 3402993 DOI: 10.1007/BF00366240.

Multilocus analysis of the fragile X syndrome.

Brown W, Gross A, Chan C, Jenkins E, Mandel J, Oberle I Hum Genet. 1988; 78(3):201-5.

PMID: 3162224 DOI: 10.1007/BF00291662.

Ten families with fragile X syndrome: linkage relationships with four DNA probes from distal Xq.

Buchanan J, BUCKTON K, Gosden C, Newton M, Clayton J, Christie S Hum Genet. 1987; 76(2):165-72.

PMID: 3038730 DOI: 10.1007/BF00284915.

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