P Jagadeeswaran
Overview
Explore the profile of P Jagadeeswaran including associated specialties, affiliations and a list of published articles.
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40
Citations
858
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Recent Articles
1.
Jagadeeswaran P, Kulkarni V, Carrillo M, Kim S
J Thromb Haemost
. 2007 Aug;
5 Suppl 1:300-4.
PMID: 17635740
Hemostasis is a defense mechanism that protects an organism from bleeding. Abnormal hemostasis results in bleeding disorders and thrombosis. Several factors are known to control hemostasis in mammals. Despite this...
2.
Jagadeeswaran P, Gregory M, Day K, Cykowski M, Thattaliyath B
J Thromb Haemost
. 2005 Jan;
3(1):46-53.
PMID: 15634265
Here we review the zebrafish hemostatic system, its relevance to mammalian hemostasis, and its efficacy as a vertebrate genetic model to further the understanding of hemostasis and thrombosis.
3.
Hanumanthaiah R, Thankavel B, Day K, Gregory M, Jagadeeswaran P
Blood Cells Mol Dis
. 2002 Feb;
27(6):992-9.
PMID: 11831865
Vitamin K-dependent gamma-carboxylation is an essential posttranslational modification required for the functional activity of coagulation proteins such as factors VII, IX, X, and prothrombin. Warfarin, an inhibitor of vitamin K-dependent...
4.
Sheehan J, Templer M, Gregory M, Hanumanthaiah R, Troyer D, Phan T, et al.
Proc Natl Acad Sci U S A
. 2001 Jul;
98(15):8768-73.
PMID: 11459993
It is not known whether the mammalian mechanism of coagulation initiation is conserved in fish. Identification of factor VII is critical in providing evidence for such a mechanism. A cDNA...
5.
Jagadeeswaran P, Gregory M, Zhou Y, Zon L, Padmanabhan K, Hanumanthaiah R
Blood Cells Mol Dis
. 2000 Dec;
26(5):479-89.
PMID: 11112385
In this paper, we report the complete cDNA sequence of zebrafish prothrombin. The cDNA sequence predicts that zebrafish prothrombin is synthesized as a pre-proprotein consisting of a Gla domain, two...
6.
Jagadeeswaran P, Gregory M, Johnson S, Thankavel B
Br J Haematol
. 2000 Oct;
110(4):946-56.
PMID: 11054087
Zebrafish were used as a model to study haemostasis, a vertebrate function of paramount importance. A limitation of the zebrafish model is the difficulty in assaying small amounts of blood...
7.
Jagadeeswaran P, Sheehan J, Craig F, Troyer D
Br J Haematol
. 1999 Dec;
107(4):731-8.
PMID: 10606877
To analyse primary haemostasis in the zebrafish we have identified and characterized the zebrafish thrombocyte by morphologic, immunologic and functional approaches. Novel methods were developed for harvesting zebrafish blood with...
8.
Jagadeeswaran P, Sheehan J
Blood Cells Mol Dis
. 1999 Nov;
25(3-4):239-49.
PMID: 10575549
The zebrafish (Danio rerio) is a unique animal model in which saturation mutagenesis has been used to identify genes involved in vertebrate development. The relevance of the zebrafish as a...
9.
Jagadeeswaran P, Liu Y, Sheehan J
Methods Cell Biol
. 1999 Jan;
59:337-57.
PMID: 9891368
No abstract available.
10.
Jagadeeswaran P, Liu Y, EDDY C
Blood Cells Mol Dis
. 1998 Mar;
23(3):410-4.
PMID: 9446755
To address the role of thrombin in early embryogenesis, hirudin, a thrombin specific inhibitor was microinjected into developing zebrafish embryos to inhibit the temporal activity of thrombin during early embryonic...