Effect of Synbiotic Supplementation on Obesity and Gut Microbiota in Obese Adults: a Double-blind Randomized Controlled Trial

Overview

Journal Front Nutr

Specialty Nutritional Sciences

Date 2024 Dec 12

PMID 39664910

Authors

Xiaokang Niu

Qi Zhang

Julong Liu

Yuyang Zhao

Nan Shang

Shusen Li

Yinghua Liu

Wei Xiong

Erna Sun

Yong Zhang

Hongfeng Zhao

Yixuan Li

Pengjie Wang

Bing Fang

Liang Zhao

Juan Chen

Fuqing Wang

Guofang Pang

Chenyuan Wang

Jingjing He

Ran Wang

Affiliations

Soon will be listed here.

Abstract

Background: Synbiotics, combining specific probiotics and selected prebiotics, may benefit health issues like obesity, but evidence remains inconsistent.

Objective: This study aimed to verify the effect of a pre-screened synbiotics combination [containing subsp. MN-Gup (MN-Gup), galacto-oligosaccharides (GOS) and xylo-oligosaccharides (XOS)] on obesity in the population.

Methods: In a randomized, double-blind, placebo-controlled trial, 80 individuals with obesity consumed daily synbiotics (containing MN-Gup 1 × 10 CFU/day, GOS 0.7 g/day, and XOS 0.7 g/day) or placebo for 12 weeks. Body composition, blood lipids, serum hormone, bile acids, and gut microbiota were measured pre-and post-intervention.

Results: Synbiotics supplementation significantly decreased body fat percentage, waist, and serum low-density lipoprotein cholesterol (LDL-C), increased peptide YY, cholecystokinin, oxyntomodulin, GSH (glutathione peroxidase) in individuals with obesity. Additionally, synbiotic supplementation led to an enrichment of beneficial bacteria and bile acids chenodeoxycholic acid (CDCA). and were significantly positively correlated with CDCA. A more favorable effect was observed in individuals with obesity and abnormal LDL-C compared to those without dyslipidemia.

Conclusion: Twelve-week synbiotics intervention reduced body fat percentage, waist, and serum LDL-C, especially in individuals with obesity and abnormal LDL-C. The possible mechanisms may be related to changes in gut microbiota, bile acids and gut hormones.

Clinical Trial Registration: Chictr.org.cn, identifier ChiCTR2200064156.

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