Expression of Serum MiR-135a in Patients with Allergic Rhinitis and Its Relationship with Treg/Th17 Balance

Overview

Journal Kaohsiung J Med Sci

Specialty General Medicine

Date 2024 Dec 11

PMID 39661490

Authors

Jing Cai

Fang Wang

Sheng-Liu Shi

Affiliations

Soon will be listed here.

Abstract

The dysregulation of microRNA (miRNA) expression contributes to the development of allergic rhinitis (AR). This study investigates serum miR-135a levels and their association with regulatory T cell (Treg) and T helper cell 17 (Th17) balance in AR patients. A total of 93 AR patients and 76 healthy controls were retrospectively recruited. Levels of serum miR-135a, peripheral blood Th17 and Treg cells, and Treg/Th17-related cytokines were measured. We assessed the diagnostic value of serum miR-135a for AR and its relationship with Treg/Th17 balance. AR patients showed significantly elevated immunoglobulin E (IgE), peripheral blood Th17 cells, and IL-17 and IL-6 levels, alongside reduced serum miR-135a, Treg cells, IL-10, TGF-β1, and Treg/Th17 ratios. A serum miR-135a of ≤0.536 demonstrated diagnostic potential for AR. Patients with higher serum miR-135a levels displayed increased Treg cell level and Treg/Th17 ratios, reduced Th17 cell, and lower total nasal symptom score (TNSS). Serum miR-135a levels in AR patients negatively correlated with TNSS, IL-17, IL-6, and Th17 cell percentages, and positively correlated with IL-10, TGF-β1, Treg cell percentages, and Treg/Th17 ratios. Collectively, decreased serum miR-135a levels in AR patients are associated with Treg/Th17 balance, supporting miR-135a as a potential biomarker for AR diagnosis.

Citing Articles

Expression of serum miR-135a in patients with allergic rhinitis and its relationship with Treg/Th17 balance.

Cai J, Wang F, Shi S Kaohsiung J Med Sci. 2024; 41(1):e12918.

PMID: 39661490 PMC: 11724171. DOI: 10.1002/kjm2.12918.

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