Genomic Perspective on the Bacillus Causing Paratyphoid B Fever

Overview

Journal Nat Commun

Specialty Biology

Date 2024 Dec 10

PMID 39658567

Authors

Jane Hawkey

Lise Frezal

Alicia Tran Dien

Anna Zhukova

Derek Brown

Marie Anne Chattaway

Sandra Simon

Hidemasa Izumiya

Patricia I Fields

Niall De Lappe

Lidia Kaftyreva

Xuebin Xu

Junko Isobe

Dominique Clermont

Elisabeth Njamkepo

Yukihiro Akeda

Sylvie Issenhuth-Jeanjean

Mariia Makarova

Yanan Wang

Martin Hunt

Brent M Jenkins

Magali Ravel

Veronique Guibert

Estelle Serre

Zoya Matveeva

Laetitia Fabre

Martin Cormican

Min Yue

Baoli Zhu

Masatomo Morita

Zamin Iqbal

Carolina Silva Nodari

Maria Pardos de la Gandara

Francois-Xavier Weill

Affiliations

Soon will be listed here.

Abstract

Paratyphoid B fever (PTB) is caused by an invasive lineage (phylogroup 1, PG1) of Salmonella enterica serotype Paratyphi B (SPB). However, little was known about the global population structure, geographic distribution, and evolution of this pathogen. Here, we report a whole-genome analysis of 568 historical and contemporary SPB PG1 isolates, obtained globally, between 1898 and 2021. We show that this pathogen existed in the 13th century, subsequently diversifying into 11 lineages and 38 genotypes with strong phylogeographic patterns. Following its discovery in 1896, it circulated across Europe until the 1970s, after which it was mostly reimported into Europe from South America, the Middle East, South Asia, and North Africa. Antimicrobial resistance recently emerged in various genotypes of SPB PG1, mostly through mutations of the quinolone-resistance-determining regions of gyrA and gyrB. This study provides an unprecedented insight into SPB PG1 and essential genomic tools for identifying and tracking this pathogen, thereby facilitating the global genomic surveillance of PTB.

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