The Dietary Inflammatory Index and Asthma Prevalence: a Cross-sectional Analysis from NHANES

Overview

Journal Front Nutr

Specialty Nutritional Sciences

Date 2024 Dec 9

PMID 39650711

Authors

Chuansen Lu

Yike Zhu

Affiliations

Soon will be listed here.

Abstract

Background: Inflammation is a key factor in the development of asthma, and diet significantly influences inflammatory responses. This study examines the relationship between the Dietary Inflammatory Index (DII) and asthma prevalence.

Methods: We conducted a cross-sectional analysis using data from the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018. Demographic details, anthropometric measurements, dietary habits, lifestyle factors, and asthma status were recorded for all participants. Multivariable logistic regression was utilized to assess the relationship between DII and asthma prevalence. Additionally, restricted cubic spline (RCS) analysis was employed to explore the nonlinearity and dose-response relationship between DII and asthma risk. Subgroup analyses were stratified by gender, age, race, body mass index (BMI), poverty income ratio (PIR), education, smoking status, alcohol use, and family medical history to dissect the association between DII and asthma across diverse populations.

Results: The analysis included 37,283 adults from NHANES. After adjusting for potential confounders in the multivariable logistic regression model, a significant positive association was identified between DII and asthma (OR, 95% CI: 1.05, 1.02-1.09, per 1 SD increase). The RCS analysis revealed a nonlinear association ( for nonlinearity = 0.0026), with an inflection point at 1.366, beyond which an increase in DII was significantly associated with asthma risk. Furthermore, the stratified analyses indicated a positive association between DII and asthma in the majority of subgroups.

Conclusion: The findings underscore a significant and nonlinear association between DII and asthma. To enhance asthma prevention and management, greater emphasis should be placed on modulating dietary-induced inflammation.

References

Tiotiu A, Badi Y, Kermani N, Sanak M, Kolmert J, Wheelock C . Association of Differential Mast Cell Activation with Granulocytic Inflammation in Severe Asthma. Am J Respir Crit Care Med. 2021; 205(4):397-411. DOI: 10.1164/rccm.202102-0355OC. View

Beaumont M, Portune K, Steuer N, Lan A, Cerrudo V, Audebert M . Quantity and source of dietary protein influence metabolite production by gut microbiota and rectal mucosa gene expression: a randomized, parallel, double-blind trial in overweight humans. Am J Clin Nutr. 2017; 106(4):1005-1019. DOI: 10.3945/ajcn.117.158816. View

Moreira A, Texeira T, Ferreira A, Gouveia Peluzio M, de Cassia Goncalves Alfenas R . Influence of a high-fat diet on gut microbiota, intestinal permeability and metabolic endotoxaemia. Br J Nutr. 2012; 108(5):801-9. DOI: 10.1017/S0007114512001213. View

Chiu C, Chan Y, Tsai M, Wang C, Chiang M, Chiu C . Gut microbial dysbiosis is associated with allergen-specific IgE responses in young children with airway allergies. World Allergy Organ J. 2019; 12(3):100021. PMC: 6439417. DOI: 10.1016/j.waojou.2019.100021. View

Ahuja J, Moshfegh A, Holden J, Harris E . USDA food and nutrient databases provide the infrastructure for food and nutrition research, policy, and practice. J Nutr. 2012; 143(2):241S-9S. DOI: 10.3945/jn.112.170043. View

Peters M, Mauger D, Ross K, Phillips B, Gaston B, Cardet J . Evidence for Exacerbation-Prone Asthma and Predictive Biomarkers of Exacerbation Frequency. Am J Respir Crit Care Med. 2020; 202(7):973-982. PMC: 7528796. DOI: 10.1164/rccm.201909-1813OC. View

Stern J, Pier J, Litonjua A . Asthma epidemiology and risk factors. Semin Immunopathol. 2020; 42(1):5-15. DOI: 10.1007/s00281-020-00785-1. View

Beam A, Clinger E, Hao L . Effect of Diet and Dietary Components on the Composition of the Gut Microbiota. Nutrients. 2021; 13(8). PMC: 8398149. DOI: 10.3390/nu13082795. View

Adamcakova J, Balentova S, Barosova R, Hanusrichterova J, Mikolka P, Prso K . Effects of Green Tea Polyphenol Epigallocatechin-3-Gallate on Markers of Inflammation and Fibrosis in a Rat Model of Pulmonary Silicosis. Int J Mol Sci. 2023; 24(3). PMC: 9916388. DOI: 10.3390/ijms24031857. View

10.

Porsbjerg C, Melen E, Lehtimaki L, Shaw D . Asthma. Lancet. 2023; 401(10379):858-873. DOI: 10.1016/S0140-6736(22)02125-0. View

11.

Banno A, Reddy A, Lakshmi S, Reddy R . Bidirectional interaction of airway epithelial remodeling and inflammation in asthma. Clin Sci (Lond). 2020; 134(9):1063-1079. DOI: 10.1042/CS20191309. View

12.

Zmora N, Suez J, Elinav E . You are what you eat: diet, health and the gut microbiota. Nat Rev Gastroenterol Hepatol. 2018; 16(1):35-56. DOI: 10.1038/s41575-018-0061-2. View

13.

Borsini A, Nicolaou A, Camacho-Munoz D, Kendall A, Di Benedetto M, Giacobbe J . Omega-3 polyunsaturated fatty acids protect against inflammation through production of LOX and CYP450 lipid mediators: relevance for major depression and for human hippocampal neurogenesis. Mol Psychiatry. 2021; 26(11):6773-6788. PMC: 8760043. DOI: 10.1038/s41380-021-01160-8. View

14.

Krusche J, Twardziok M, Rehbach K, Bock A, Tsang M, Schroder P . TNF-α-induced protein 3 is a key player in childhood asthma development and environment-mediated protection. J Allergy Clin Immunol. 2019; 144(6):1684-1696.e12. DOI: 10.1016/j.jaci.2019.07.029. View

15.

Samuelson D, Welsh D, Shellito J . Regulation of lung immunity and host defense by the intestinal microbiota. Front Microbiol. 2015; 6:1085. PMC: 4595839. DOI: 10.3389/fmicb.2015.01085. View

16.

Sdona E, Ekstrom S, Andersson N, Hallberg J, Rautiainen S, Hakansson N . Fruit, vegetable and dietary antioxidant intake in school age, respiratory health up to young adulthood. Clin Exp Allergy. 2021; 52(1):104-114. DOI: 10.1111/cea.14020. View

17.

Trompette A, Gollwitzer E, Yadava K, Sichelstiel A, Sprenger N, Ngom-Bru C . Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis. Nat Med. 2014; 20(2):159-66. DOI: 10.1038/nm.3444. View

18.

Denova-Gutierrez E, Munoz-Aguirre P, Shivappa N, Hebert J, Tolentino-Mayo L, Batis C . Dietary Inflammatory Index and Type 2 Diabetes Mellitus in Adults: The Diabetes Mellitus Survey of Mexico City. Nutrients. 2018; 10(4). PMC: 5946170. DOI: 10.3390/nu10040385. View

19.

Hebert J, Shivappa N, Wirth M, Hussey J, Hurley T . Perspective: The Dietary Inflammatory Index (DII)-Lessons Learned, Improvements Made, and Future Directions. Adv Nutr. 2019; 10(2):185-195. PMC: 6416047. DOI: 10.1093/advances/nmy071. View

20.

Wen J, Wang C, Giri M, Guo S . Association between serum folate levels and blood eosinophil counts in American adults with asthma: Results from NHANES 2011-2018. Front Immunol. 2023; 14:1134621. PMC: 9993087. DOI: 10.3389/fimmu.2023.1134621. View