SnoRNAs: The Promising Targets for Anti-tumor Therapy

Overview

Journal J Pharm Anal

Specialty Chemistry

Date 2024 Dec 5

PMID 39634568

Authors

Xiaoyun Hu

Wanlin Cui

Min Liu

Fangxiao Zhang

Yingqi Zhao

Mingrong Zhang

Yuhang Yin

Yalun Li

Ying Che

Xianglong Zhu

Yuxuan Fan

Xiaolan Deng

Minjie Wei

Huizhe Wu

Affiliations

Soon will be listed here.

Abstract

Recently, small nucleolar RNAs (snoRNAs) have transcended the genomic "noise" to emerge as pivotal molecular markers due to their essential roles in tumor progression. Substantial evidence indicates a strong association between snoRNAs and critical clinical features such as tumor pathology and drug resistance. Historically, snoRNA research has concentrated on two classical mechanisms: 2'--ribose methylation and pseudouridylation. This review specifically summarizes the novel regulatory mechanisms and functional patterns of snoRNAs in tumors, encompassing transcriptional, post-transcriptional, and post-translational regulation. We further discuss the synergistic effect between snoRNA host genes (SNHGs) and snoRNAs in tumor progression. More importantly, snoRNAs extensively contribute to the development of tumor cell resistance as oncogenes or tumor suppressor genes. Accordingly, we provide a comprehensive review of the clinical diagnosis and treatment associated with snoRNAs and explore their significant potential as novel drug targets.

Citing Articles

Non-Coding RNAs in Cancer: Structure, Function, and Clinical Application.

Marton E, Varga A, Domoszlai D, Buglyo G, Balazs A, Penyige A Cancers (Basel). 2025; 17(4).

PMID: 40002172 PMC: 11853212. DOI: 10.3390/cancers17040579.

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