Ultra-high Dose Rate (FLASH) Radiotherapy: Revolutionizing Tumor Targeting and Microenvironmental Dynamics in Cancer Treatment

Overview

Journal Chin Med J (Engl)

Specialty General Medicine

Date 2024 Nov 29

PMID 39609951

Authors

Zhiming Wang

Guangming Zhou

Yongsheng Zhang

Zhifei Cao

Affiliations

Soon will be listed here.

References

Zhu H, Xie D, Wang Y, Huang R, Chen X, Yang Y . Comparison of intratumor and local immune response between MV X-ray FLASH and conventional radiotherapies. Clin Transl Radiat Oncol. 2022; 38:138-146. PMC: 9679438. DOI: 10.1016/j.ctro.2022.11.005. View

Padilla O, Minns H, Wei H, Fan W, Webster-Carrion A, Tazhibi M . Immune Response following FLASH and Conventional Radiation in Diffuse Midline Glioma. Int J Radiat Oncol Biol Phys. 2024; 119(4):1248-1260. PMC: 11209798. DOI: 10.1016/j.ijrobp.2024.01.219. View

Barghouth P, Melemenidis S, Montay-Gruel P, Ollivier J, Viswanathan V, Jorge P . FLASH-RT does not affect chromosome translocations and junction structures beyond that of CONV-RT dose-rates. Radiother Oncol. 2023; 188:109906. PMC: 10591966. DOI: 10.1016/j.radonc.2023.109906. View

Leavitt R, Almeida A, Grilj V, Montay-Gruel P, Godfroid C, Petit B . Acute Hypoxia Does Not Alter Tumor Sensitivity to FLASH Radiation Therapy. Int J Radiat Oncol Biol Phys. 2024; 119(5):1493-1505. DOI: 10.1016/j.ijrobp.2024.02.015. View

Velalopoulou A, Karagounis I, Cramer G, Kim M, Skoufos G, Goia D . FLASH Proton Radiotherapy Spares Normal Epithelial and Mesenchymal Tissues While Preserving Sarcoma Response. Cancer Res. 2021; 81(18):4808-4821. PMC: 8715480. DOI: 10.1158/0008-5472.CAN-21-1500. View

Buonanno M, Grilj V, Brenner D . Biological effects in normal cells exposed to FLASH dose rate protons. Radiother Oncol. 2019; 139:51-55. PMC: 6728238. DOI: 10.1016/j.radonc.2019.02.009. View

Shi X, Yang Y, Zhang W, Wang J, Xiao D, Ren H . FLASH X-ray spares intestinal crypts from pyroptosis initiated by cGAS-STING activation upon radioimmunotherapy. Proc Natl Acad Sci U S A. 2022; 119(43):e2208506119. PMC: 9618056. DOI: 10.1073/pnas.2208506119. View

Kim Y, Gwak S, Hong B, Oh J, Choi H, Kim M . Effects of Ultra-high doserate FLASH Irradiation on the Tumor Microenvironment in Lewis Lung Carcinoma: Role of Myosin Light Chain. Int J Radiat Oncol Biol Phys. 2020; 109(5):1440-1453. DOI: 10.1016/j.ijrobp.2020.11.012. View

Borghini A, Labate L, Piccinini S, Panaino C, Andreassi M, Gizzi L . FLASH Radiotherapy: Expectations, Challenges, and Current Knowledge. Int J Mol Sci. 2024; 25(5). PMC: 10932202. DOI: 10.3390/ijms25052546. View

10.

Shukla S, Saha T, Rama N, Acharya A, Le T, Bian F . Ultra-high dose-rate proton FLASH improves tumor control. Radiother Oncol. 2023; 186:109741. PMC: 10527231. DOI: 10.1016/j.radonc.2023.109741. View

11.

Allen B, Acharya M, Montay-Gruel P, Goncalves Jorge P, Bailat C, Petit B . Maintenance of Tight Junction Integrity in the Absence of Vascular Dilation in the Brain of Mice Exposed to Ultra-High-Dose-Rate FLASH Irradiation. Radiat Res. 2020; 194(6):625-635. PMC: 7773228. DOI: 10.1667/RADE-20-00060.1. View

12.

Iturri L, Bertho A, Lamirault C, Juchaux M, Gilbert C, Espenon J . Proton FLASH Radiation Therapy and Immune Infiltration: Evaluation in an Orthotopic Glioma Rat Model. Int J Radiat Oncol Biol Phys. 2022; 116(3):655-665. DOI: 10.1016/j.ijrobp.2022.12.018. View