» Articles » PMID: 39593756

Applications, Limitations, and Considerations of Clinical Trials in a Dish

Overview
Date 2024 Nov 27
PMID 39593756
Authors
Affiliations
Soon will be listed here.
Abstract

Recent advancements in biotechnology forged the path for clinical trials in dish (CTiDs) to advance as a popular method of experimentation in biomedicine. CTiDs play a fundamental role in translational research through technologies such as induced pluripotent stem cells, whole genome sequencing, and organs-on-a-chip. In this review, we explore advancements that enable these CTiD biotechnologies and their applications in animal testing, disease modeling, and space radiation technologies. Furthermore, this review dissects the advantages and disadvantages of CTiDs, as well as their regulatory considerations. Lastly, we evaluate the challenges that CTiDs pose and the role of CTiDs in future experimentation.

References
1.
Martin R, Biswas P, Freemantle S, Pearce G, Mann R . Age and sex distribution of suspected adverse drug reactions to newly marketed drugs in general practice in England: analysis of 48 cohort studies. Br J Clin Pharmacol. 1998; 46(5):505-11. PMC: 1873702. DOI: 10.1046/j.1365-2125.1998.00817.x. View

2.
Granata A, Serrano F, Bernard W, McNamara M, Low L, Sastry P . An iPSC-derived vascular model of Marfan syndrome identifies key mediators of smooth muscle cell death. Nat Genet. 2016; 49(1):97-109. DOI: 10.1038/ng.3723. View

3.
Holmgren G, Synnergren J, Bogestal Y, Ameen C, Akesson K, Holmgren S . Identification of novel biomarkers for doxorubicin-induced toxicity in human cardiomyocytes derived from pluripotent stem cells. Toxicology. 2014; 328:102-11. PMC: 4326176. DOI: 10.1016/j.tox.2014.12.018. View

4.
Ahmed S, Shivnaraine R, Wu J . FDA Modernization Act 2.0 Paves the Way to Computational Biology and Clinical Trials in a Dish. Circulation. 2023; 148(4):309-311. PMC: 10902210. DOI: 10.1161/CIRCULATIONAHA.123.065585. View

5.
Fermini B, Coyne S, Coyne K . Clinical Trials in a Dish: A Perspective on the Coming Revolution in Drug Development. SLAS Discov. 2018; 23(8):765-776. PMC: 6104197. DOI: 10.1177/2472555218775028. View