Ischemia-Modified Albumin and Antioxidant Capacity of Blood Serum in Normal Pregnancy and Preeclampsia

Overview

Journal Bull Exp Biol Med

Publisher Springer

Specialty General Medicine

Date 2024 Nov 21

PMID 39572493

Authors

Yu O Teselkin

I V Babenkova

S Yu Lebedeva

Yu V Vykhristyuk

R I Shalina

V Yu Titov

M A Kurtser

Yu A Vladimirov

A N Osipov

Affiliations

Soon will be listed here.

Abstract

A comparative study of oxidative stress markers (ischemia-modified albumin (IMA) and the blood serum antioxidant capacity) in normal pregnancy and preeclampsia was carried out. The IMA level and blood serum antioxidant capacity increased in the following order: healthy non-pregnant women→healthy pregnant women→patients with moderate preeclampsia→patients with severe preeclampsia (p<0.001). A significant positive correlation was revealed between blood serum antioxidant capacity and uric acid levels in all the examined groups. The results showed that oxidative stress in preeclampsia is more pronounced compared to normal pregnancy. The levels of IMA and the blood serum antioxidant capacity can be additional criteria for assessment of the severity of preeclampsia and predicting of its course.

References

Chiarello D, Abad C, Rojas D, Toledo F, Vazquez C, Mate A . Oxidative stress: Normal pregnancy versus preeclampsia. Biochim Biophys Acta Mol Basis Dis. 2018; 1866(2):165354. DOI: 10.1016/j.bbadis.2018.12.005. View

Dimitriadis E, Rolnik D, Zhou W, Estrada-Gutierrez G, Koga K, Francisco R . Pre-eclampsia. Nat Rev Dis Primers. 2023; 9(1):8. DOI: 10.1038/s41572-023-00417-6. View

Haram K, Mortensen J, Myking O, Magann E, Morrison J . The Role of Oxidative Stress, Adhesion Molecules and Antioxidants in Preeclampsia. Curr Hypertens Rev. 2019; 15(2):105-112. DOI: 10.2174/1573402115666190119163942. View

Afrose D, Chen H, Ranashinghe A, Liu C, Henessy A, Hansbro P . The diagnostic potential of oxidative stress biomarkers for preeclampsia: systematic review and meta-analysis. Biol Sex Differ. 2022; 13(1):26. PMC: 9167545. DOI: 10.1186/s13293-022-00436-0. View

Dsouza J, Pai V, Harish S, Shriyan C, Dsouza N . IMA and IMAR in serum and saliva of preeclampsia--a preliminary study. Hypertens Pregnancy. 2014; 33(4):440-8. DOI: 10.3109/10641955.2014.931418. View

Dahiya K, Kulshrestha M, Bansal P, Ghalaut V, Kulshrestha R, Dahiya P . Evaluation of cord blood ischemia modified albumin in normal pregnancies and pre-eclampsia. Hypertens Pregnancy. 2015; 34(2):204-8. DOI: 10.3109/10641955.2014.1001901. View

Madazli R, Benian A, Aydin S, Uzun H, Tolun N . The plasma and placental levels of malondialdehyde, glutathione and superoxide dismutase in pre-eclampsia. J Obstet Gynaecol. 2003; 22(5):477-80. DOI: 10.1080/0144361021000003573. View

Atamer Y, Kocyigit Y, Yokus B, Atamer A, Erden A . Lipid peroxidation, antioxidant defense, status of trace metals and leptin levels in preeclampsia. Eur J Obstet Gynecol Reprod Biol. 2005; 119(1):60-6. DOI: 10.1016/j.ejogrb.2004.06.033. View

Leon-Reyes G, Maida-Claros R, Urrutia-Medina A, Jorge-Galarza E, Guzman-Grenfell A, Fuentes-Garcia S . Oxidative profiles of LDL and HDL isolated from women with preeclampsia. Lipids Health Dis. 2017; 16(1):90. PMC: 5434532. DOI: 10.1186/s12944-017-0480-z. View

10.

Uotila J, Kirkkola A, Rorarius M, Tuimala R . The total peroxyl radical-trapping ability of plasma and cerebrospinal fluid in normal and preeclamptic parturients. Free Radic Biol Med. 1994; 16(5):581-90. DOI: 10.1016/0891-5849(94)90058-2. View

11.

Llurba E, Gratacos E, Martin-Gallan P, Cabero L, Dominguez C . A comprehensive study of oxidative stress and antioxidant status in preeclampsia and normal pregnancy. Free Radic Biol Med. 2004; 37(4):557-70. DOI: 10.1016/j.freeradbiomed.2004.04.035. View

12.

Harma M, Harma M, Erel O . Measurement of the total antioxidant response in preeclampsia with a novel automated method. Eur J Obstet Gynecol Reprod Biol. 2004; 118(1):47-51. DOI: 10.1016/j.ejogrb.2004.04.012. View

13.

Adiga U, DSouza V, Kamath A, Mangalore N . Antioxidant activity and lipid peroxidation in preeclampsia. J Chin Med Assoc. 2007; 70(10):435-8. DOI: 10.1016/S1726-4901(08)70034-0. View

14.

Bar-Or D, Lau E, Winkler J . A novel assay for cobalt-albumin binding and its potential as a marker for myocardial ischemia-a preliminary report. J Emerg Med. 2000; 19(4):311-5. DOI: 10.1016/s0736-4679(00)00255-9. View

15.

Basu J, Bendek B, Agamasu E, Salafia C, Mishra A, Benfield N . Placental Oxidative Status throughout Normal Gestation in Women with Uncomplicated Pregnancies. Obstet Gynecol Int. 2015; 2015:276095. PMC: 4333282. DOI: 10.1155/2015/276095. View

16.

Kang D, Finch J, Nakagawa T, Karumanchi S, Kanellis J, Granger J . Uric acid, endothelial dysfunction and pre-eclampsia: searching for a pathogenetic link. J Hypertens. 2004; 22(2):229-35. DOI: 10.1097/00004872-200402000-00001. View

17.

Lam C, Lim K, Kang D, Karumanchi S . Uric acid and preeclampsia. Semin Nephrol. 2005; 25(1):56-60. DOI: 10.1016/j.semnephrol.2004.09.009. View