Uric Acid, Endothelial Dysfunction and Pre-eclampsia: Searching for a Pathogenetic Link

Overview

Journal J Hypertens

Specialty Cardiology & Vascular Diseases

Date 2004 Apr 13

PMID 15076175

Citations 28

Authors

Duk-Hee Kang

Jennifer Finch

Takahiko Nakagawa

S Ananth Karumanchi

John Kanellis

Joey Granger

Richard J Johnson

Affiliations

Soon will be listed here.

Abstract

Background: Pre-eclampsia is strongly associated with hyperuricemia, and in some studies the increase in serum uric acid has been found to correlate with both maternal and fetal morbidity. The hyperuricemia is believed to result primarily from the decreased renal excretion that occurs as a consequence of the pre-eclampsia, and as such is widely viewed as a marker for pre-eclampsia as opposed to having a role in the pathogenesis.

Hypothesis: We present the hypothesis that hyperuricemia may also have a contributory role in the development of hypertension and renal disease in these patients, and we review recent experimental data that would support this hypothesis.

Recommendation: We suggest that studies addressing the role of uric acid in pre-eclampsia may provide new insights into both the pathogenesis and treatment of this condition.

Citing Articles

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The association between serum uric acid and low birth weight in advance maternal age women with hypertension: An observational study.

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Critical Hypermagnesemia in Preeclamptic Women Under a Magnesium Sulfate Regimen: Incidence and Associated Risk Factors.

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Periodontal Inflamed Surface Area Is Associated With Increased Gestational Blood Pressure and Uric Acid Levels Among Pregnant Women From Rural North China.

Hu S, Yu F, Jiang H, Shang W, Miao H, Li S Front Cardiovasc Med. 2022; 9:830732.

PMID: 35299983 PMC: 8921456. DOI: 10.3389/fcvm.2022.830732.

Association of Maternal Serum Uric Acid and Cystatin C Levels in Late Pregnancy with Adverse Birth Outcomes: An Observational Cohort Study in China.

Yuan X, Han X, Jia C, Wang H, Yu B Int J Womens Health. 2022; 14:213-223.

PMID: 35210868 PMC: 8860627. DOI: 10.2147/IJWH.S350847.