The Longitudinal Relationship Between Brain Morphology and Obsessive-Compulsive Symptoms in Children From the General Population

Overview

Journal JAACAP Open

Date 2024 Nov 18

PMID 39554206

Authors

Cees J Weeland

Chris Vriend

Henning Tiemeier

Odile A van den Heuvel

Tonya White

Affiliations

Soon will be listed here.

Abstract

Objective: Cross-sectional studies in children with obsessive-compulsive disorder (OCD) have found larger thalamic volume, which is not found at later ages. We previously found that 9- to 12-year-old children from the general population with clinical-level obsessive-compulsive symptoms (OCS) also have a larger thalamus. Thus, using a longitudinal design, we studied the relationship among thalamic volume, cortical maturation, and the course of OCS.

Method: Children from the population-based Generation R Study underwent 1 or 2 (N = 2,552) magnetic resonance imaging (MRI) scans between the age of 9 and 16 years (baseline 9-12 years, follow-up 13-16 years). OCS were assessed with the Short Obsessive-Compulsive Disorder Screener (SOCS) questionnaire using both continuous and clinical cut-off measures to identify children with "probable OCD." We applied linear regression models to investigate the cross-sectional relationship between brain morphology and OCS at age 13 to 16 years. Linear mixed-effect models were fitted to model the bidirectional longitudinal relationship between thalamus and OCS and the thalamus and cortical morphology.

Results: Thalamic volume was not different between probable OCD cases and controls at age 13 to 16 years. Higher baseline thalamic volume predicted a relative persistence of OCS and a flatter slope of thinning in 12 cortical regions.

Conclusion: Larger thalamic volume may be a subtle biomarker for persistent OCS symptoms. The persistence of OCS and cortical thickness in relation to earlier larger thalamic volume may reflect being at an earlier stage in neurodevelopment. Longitudinal designs with repeated multimodal brain imaging are warranted to improve our understanding of the neurodevelopmental processes underlying OCS and OCD.

Study Preregistration Information: Relationship between obsessive-compulsive symptoms and brain morphology in school-aged children in the general population; https://osf.io/; y6vs2.

References

Boedhoe P, Schmaal L, Abe Y, Ameis S, Arnold P, Batistuzzo M . Distinct Subcortical Volume Alterations in Pediatric and Adult OCD: A Worldwide Meta- and Mega-Analysis. Am J Psychiatry. 2016; 174(1):60-69. PMC: 5344782. DOI: 10.1176/appi.ajp.2016.16020201. View

Brander G, Rydell M, Kuja-Halkola R, Fernandez de la Cruz L, Lichtenstein P, Serlachius E . Association of Perinatal Risk Factors With Obsessive-Compulsive Disorder: A Population-Based Birth Cohort, Sibling Control Study. JAMA Psychiatry. 2016; 73(11):1135-1144. DOI: 10.1001/jamapsychiatry.2016.2095. View

Vattimo E, Barros V, Requena G, Sato J, Fatori D, Miguel E . Caudate volume differences among treatment responders, non-responders and controls in children with obsessive-compulsive disorder. Eur Child Adolesc Psychiatry. 2019; 28(12):1607-1617. DOI: 10.1007/s00787-019-01320-w. View

Weeland C, Kasprzak S, de Joode N, Abe Y, Alonso P, Ameis S . The thalamus and its subnuclei-a gateway to obsessive-compulsive disorder. Transl Psychiatry. 2022; 12(1):70. PMC: 8861046. DOI: 10.1038/s41398-022-01823-2. View

Lazaro L, Bargallo N, Castro-Fornieles J, Falcon C, Andres S, Calvo R . Brain changes in children and adolescents with obsessive-compulsive disorder before and after treatment: a voxel-based morphometric MRI study. Psychiatry Res. 2009; 172(2):140-6. DOI: 10.1016/j.pscychresns.2008.12.007. View

Lenroot R, Gogtay N, Greenstein D, Wells E, Wallace G, Clasen L . Sexual dimorphism of brain developmental trajectories during childhood and adolescence. Neuroimage. 2007; 36(4):1065-73. PMC: 2040300. DOI: 10.1016/j.neuroimage.2007.03.053. View

Boedhoe P, Schmaal L, Abe Y, Alonso P, Ameis S, Anticevic A . Cortical Abnormalities Associated With Pediatric and Adult Obsessive-Compulsive Disorder: Findings From the ENIGMA Obsessive-Compulsive Disorder Working Group. Am J Psychiatry. 2018; 175(5):453-462. PMC: 7106947. DOI: 10.1176/appi.ajp.2017.17050485. View

Kooijman M, Kruithof C, Van Duijn C, Duijts L, Franco O, van IJzendoorn M . The Generation R Study: design and cohort update 2017. Eur J Epidemiol. 2017; 31(12):1243-1264. PMC: 5233749. DOI: 10.1007/s10654-016-0224-9. View

Elvsashagen T, Shadrin A, Frei O, van der Meer D, Bahrami S, Kumar V . The genetic architecture of the human thalamus and its overlap with ten common brain disorders. Nat Commun. 2021; 12(1):2909. PMC: 8131358. DOI: 10.1038/s41467-021-23175-z. View

10.

Ruscio A, Stein D, Chiu W, Kessler R . The epidemiology of obsessive-compulsive disorder in the National Comorbidity Survey Replication. Mol Psychiatry. 2008; 15(1):53-63. PMC: 2797569. DOI: 10.1038/mp.2008.94. View

11.

Fitzgerald K, Welsh R, Stern E, Angstadt M, Hanna G, Abelson J . Developmental alterations of frontal-striatal-thalamic connectivity in obsessive-compulsive disorder. J Am Acad Child Adolesc Psychiatry. 2011; 50(9):938-948.e3. PMC: 3167379. DOI: 10.1016/j.jaac.2011.06.011. View

12.

Sowell E, Thompson P, Leonard C, Welcome S, Kan E, Toga A . Longitudinal mapping of cortical thickness and brain growth in normal children. J Neurosci. 2004; 24(38):8223-31. PMC: 6729679. DOI: 10.1523/JNEUROSCI.1798-04.2004. View

13.

Hudziak J, Althoff R, Stanger C, van Beijsterveldt C, Nelson E, Hanna G . The Obsessive Compulsive Scale of the Child Behavior Checklist predicts obsessive-compulsive disorder: a receiver operating characteristic curve analysis. J Child Psychol Psychiatry. 2006; 47(2):160-6. DOI: 10.1111/j.1469-7610.2005.01465.x. View

14.

Evans D, Lewis M, Iobst E . The role of the orbitofrontal cortex in normally developing compulsive-like behaviors and obsessive-compulsive disorder. Brain Cogn. 2004; 55(1):220-34. DOI: 10.1016/S0278-2626(03)00274-4. View

15.

Alexander-Bloch A, Sood R, Shinohara R, Moore T, Calkins M, Chertavian C . Connectome-wide Functional Connectivity Abnormalities in Youth With Obsessive-Compulsive Symptoms. Biol Psychiatry Cogn Neurosci Neuroimaging. 2021; 7(11):1068-1077. PMC: 8821731. DOI: 10.1016/j.bpsc.2021.07.014. View

16.

Huyser C, van den Heuvel O, Wolters L, de Haan E, Lindauer R, Veltman D . A longitudinal VBM study in paediatric obsessive-compulsive disorder at 2-year follow-up after cognitive behavioural therapy. World J Biol Psychiatry. 2013; 15(6):443-52. DOI: 10.3109/15622975.2013.819122. View

17.

Benoit L, Canetta S, Kellendonk C . Thalamocortical Development: A Neurodevelopmental Framework for Schizophrenia. Biol Psychiatry. 2022; 92(6):491-500. PMC: 9999366. DOI: 10.1016/j.biopsych.2022.03.004. View

18.

Hibar D, Cheung J, Medland S, Mufford M, Jahanshad N, Dalvie S . Significant concordance of genetic variation that increases both the risk for obsessive-compulsive disorder and the volumes of the nucleus accumbens and putamen. Br J Psychiatry. 2018; 213(1):430-436. PMC: 6053271. DOI: 10.1192/bjp.2018.62. View

19.

Szeszko P, MacMillan S, McMeniman M, Lorch E, Madden R, Ivey J . Amygdala volume reductions in pediatric patients with obsessive-compulsive disorder treated with paroxetine: preliminary findings. Neuropsychopharmacology. 2004; 29(4):826-32. DOI: 10.1038/sj.npp.1300399. View

20.

Gogtay N, Giedd J, Lusk L, Hayashi K, Greenstein D, Vaituzis A . Dynamic mapping of human cortical development during childhood through early adulthood. Proc Natl Acad Sci U S A. 2004; 101(21):8174-9. PMC: 419576. DOI: 10.1073/pnas.0402680101. View