» Articles » PMID: 39553634

Cancer Prevention at the Microscopic Level with the Potent Power of Micronutrients

Overview
Journal Heliyon
Specialty Social Sciences
Date 2024 Nov 18
PMID 39553634
Authors
Affiliations
Soon will be listed here.
Abstract

Cancer remains a leading cause of morbidity and mortality worldwide, necessitating ongoing exploration of effective prevention strategies. Micronutrients, vital for maintaining cellular health, offer promising avenues for cancer prevention. This review delineates the critical roles of micronutrients in cancer prevention, elucidating their mechanisms at the cellular level. Focusing on essential vitamins and minerals like Vitamins A, C, D, E, selenium, and zinc, we explore their profound effects on fundamental cellular processes such as DNA repair, oxidative stress regulation, cellular proliferation, and immune surveillance. These nutrients, characterized by their antioxidative, anti-inflammatory, and immune-enhancing properties, have shown potential in reducing the risk of cancer. The article synthesizes outcomes from a broad spectrum of clinical trials, epidemiological studies, and systematic reviews to evaluate the efficacy of micronutrients in thwarting cancer development. This critical analysis explores significant trials, addresses controversies in nutrient efficacy, and highlights the implications for clinical practice and public health policy. The review underscores the importance of integrating nutritional strategies into comprehensive cancer prevention frameworks and suggests directions for future research to optimize the preventive potentials of micronutrients.

References
1.
Kuria A, Fang X, Li M, Han H, He J, Aaseth J . Does dietary intake of selenium protect against cancer? A systematic review and meta-analysis of population-based prospective studies. Crit Rev Food Sci Nutr. 2018; 60(4):684-694. DOI: 10.1080/10408398.2018.1548427. View

2.
Shibata A, Paganini-Hill A, Ross R, Henderson B . Intake of vegetables, fruits, beta-carotene, vitamin C and vitamin supplements and cancer incidence among the elderly: a prospective study. Br J Cancer. 1992; 66(4):673-9. PMC: 1977409. DOI: 10.1038/bjc.1992.336. View

3.
Park Y, Spiegelman D, Hunter D, Albanes D, Bergkvist L, Buring J . Intakes of vitamins A, C, and E and use of multiple vitamin supplements and risk of colon cancer: a pooled analysis of prospective cohort studies. Cancer Causes Control. 2010; 21(11):1745-57. PMC: 3091388. DOI: 10.1007/s10552-010-9549-y. View

4.
Bomer N, Pavez-Giani M, Grote Beverborg N, Cleland J, Van Veldhuisen D, van der Meer P . Micronutrient deficiencies in heart failure: Mitochondrial dysfunction as a common pathophysiological mechanism?. J Intern Med. 2022; 291(6):713-731. PMC: 9303299. DOI: 10.1111/joim.13456. View

5.
Shao T, Klein P, Grossbard M . Vitamin D and breast cancer. Oncologist. 2012; 17(1):36-45. PMC: 3267821. DOI: 10.1634/theoncologist.2011-0278. View