Micronutrients and Breast Cancer Progression: A Systematic Review

Overview

Journal Nutrients

Date 2020 Dec 1

PMID 33255538

Citations 9

Authors

Olga Cuenca-Mico

Carmen Aceves

Affiliations

Soon will be listed here.

Abstract

Epidemiological studies on micronutrient consumption have reported protective associations in the incidence and/or progression of various cancer types. Supplementation with some of these micronutrients has been analyzed, showing chemoprotection, low toxicity, antiproliferation, and the ability to modify epigenetic signatures in various cancer models. This review investigates the reported effects of micronutrient intake or supplementation in breast cancer progression. A PubMed search was conducted with the keywords "micronutrients breast cancer progression", and the results were analyzed. The selected micronutrients were vitamins (C, D, and E), folic acid, metals (Cu, Fe, Se, and Zn), fatty acids, polyphenols, and iodine. The majority of in vitro models showed antiproliferative, cell-cycle arrest, and antimetastatic effects for almost all the micronutrients analyzed, but these effects do not reflect animal or human studies. Only one clinical trial with vitamin D and one pilot study with molecular iodine showed favorable overall survival and disease-free interval.

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References

Yuan L, Jiang R, Yang Y, Ding S, Deng H . 1,25-Dihydroxyvitamin D3 inhibits growth of the breast cancer cell line MCF-7 and downregulates cytochrome P4501B1 through the COX-2/PGE2 pathway. Oncol Rep. 2012; 28(6):2131-7. DOI: 10.3892/or.2012.2031. View

de Souza E, de Albuquerque T, Dos Santos A, Massa N, Alves J . Potential interactions among phenolic compounds and probiotics for mutual boosting of their health-promoting properties and food functionalities - A review. Crit Rev Food Sci Nutr. 2018; 59(10):1645-1659. DOI: 10.1080/10408398.2018.1425285. View

Swami S, Krishnan A, Williams J, Aggarwal A, Albertelli M, Horst R . Vitamin D mitigates the adverse effects of obesity on breast cancer in mice. Endocr Relat Cancer. 2016; 23(4):251-64. PMC: 4889430. DOI: 10.1530/ERC-15-0557. View

Dugrillon A, Uedelhoven W, Pisarev M, Bechtner G, Gartner R . Identification of delta-iodolactone in iodide treated human goiter and its inhibitory effect on proliferation of human thyroid follicles. Horm Metab Res. 1994; 26(10):465-9. DOI: 10.1055/s-2007-1001734. View

Palmieri C, MacGregor T, Girgis S, Vigushin D . Serum 25-hydroxyvitamin D levels in early and advanced breast cancer. J Clin Pathol. 2006; 59(12):1334-6. PMC: 1860540. DOI: 10.1136/jcp.2006.042747. View

Feldman D, Krishnan A, Swami S, Giovannucci E, Feldman B . The role of vitamin D in reducing cancer risk and progression. Nat Rev Cancer. 2014; 14(5):342-57. DOI: 10.1038/nrc3691. View

Khanzode S, Muddeshwar M, Khanzode S, Dakhale G . Antioxidant enzymes and lipid peroxidation in different stages of breast cancer. Free Radic Res. 2004; 38(1):81-5. DOI: 10.1080/01411590310001637066. View

Hunt J . Bioavailability of iron, zinc, and other trace minerals from vegetarian diets. Am J Clin Nutr. 2003; 78(3 Suppl):633S-639S. DOI: 10.1093/ajcn/78.3.633S. View

Alfaro Y, Delgado G, Carabez A, Anguiano B, Aceves C . Iodine and doxorubicin, a good combination for mammary cancer treatment: antineoplastic adjuvancy, chemoresistance inhibition, and cardioprotection. Mol Cancer. 2013; 12:45. PMC: 3673826. DOI: 10.1186/1476-4598-12-45. View

10.

Lubecka-Pietruszewska K, Kaufman-Szymczyk A, Stefanska B, Fabianowska-Majewska K . Folic acid enforces DNA methylation-mediated transcriptional silencing of PTEN, APC and RARbeta2 tumour suppressor genes in breast cancer. Biochem Biophys Res Commun. 2012; 430(2):623-8. DOI: 10.1016/j.bbrc.2012.11.103. View

11.

Bravo L . Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. Nutr Rev. 1998; 56(11):317-33. DOI: 10.1111/j.1753-4887.1998.tb01670.x. View

12.

Constantinou C, Charalambous C, Kanakis D . Vitamin E and cancer: an update on the emerging role of γ and δ tocotrienols. Eur J Nutr. 2019; 59(3):845-857. DOI: 10.1007/s00394-019-01962-1. View

13.

Hanf V, Gonder U . Nutrition and primary prevention of breast cancer: foods, nutrients and breast cancer risk. Eur J Obstet Gynecol Reprod Biol. 2005; 123(2):139-49. DOI: 10.1016/j.ejogrb.2005.05.011. View

14.

Chen Q, Espey M, Sun A, Pooput C, Kirk K, Krishna M . Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice. Proc Natl Acad Sci U S A. 2008; 105(32):11105-9. PMC: 2516281. DOI: 10.1073/pnas.0804226105. View

15.

Prasad A, BECK F, Doerr T, Shamsa F, Penny H, Marks S . Nutritional and zinc status of head and neck cancer patients: an interpretive review. J Am Coll Nutr. 1998; 17(5):409-18. DOI: 10.1080/07315724.1998.10718787. View

16.

Costello L, Zou J, Franklin R . In situ clinical evidence that zinc levels are decreased in breast invasive ductal carcinoma. Cancer Causes Control. 2016; 27(6):729-35. PMC: 4871763. DOI: 10.1007/s10552-016-0746-1. View

17.

Ulrich C, Potter J . Folate and cancer--timing is everything. JAMA. 2007; 297(21):2408-9. DOI: 10.1001/jama.297.21.2408. View

18.

Feuerecker B, Pirsig S, Seidl C, Aichler M, Feuchtinger A, Bruchelt G . Lipoic acid inhibits cell proliferation of tumor cells in vitro and in vivo. Cancer Biol Ther. 2012; 13(14):1425-35. PMC: 3542233. DOI: 10.4161/cbt.22003. View

19.

Nava-Villalba M, Nunez-Anita R, Bontempo A, Aceves C . Activation of peroxisome proliferator-activated receptor gamma is crucial for antitumoral effects of 6-iodolactone. Mol Cancer. 2015; 14:168. PMC: 4573306. DOI: 10.1186/s12943-015-0436-8. View

20.

Ganz T . Hepcidin and iron regulation, 10 years later. Blood. 2011; 117(17):4425-33. PMC: 3099567. DOI: 10.1182/blood-2011-01-258467. View