Development of Novel Osteoarthritis Therapy by Targeting AMPK-β-catenin-Runx2 Signaling

Overview

Journal Genes Dis

Date 2024 Nov 18

PMID 39552787

Authors

Daofu Zeng

Muhammad Umar

Zhenglin Zhu

Haobo Pan

William W Lu

Guozhi Xiao

Yan Chen

Liping Tong

Di Chen

Affiliations

Soon will be listed here.

Abstract

Osteoarthritis (OA) is a debilitating chronic joint disease affecting large populations of patients, especially the elderly. The pathological mechanisms of OA are currently unknown. Multiple risk factors are involved in OA development. Among these risk factors, alterations of mechanical loading in the joint leading to changes in biological signaling pathways have been known as a key event in OA development. The importance of AMPK-β-catenin-Runx2 signaling in the initiation and progression of OA has been recognized in recent years. In this review, we discuss the recent progress in understanding the role of this signaling pathway and the underlying interaction mechanisms during OA development. We also discuss the drug development aiming to target this signaling pathway for OA treatment.

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