Perinatal Psychoneuroimmunology of Prenatal Stress and Its Effects on Fetal and Postnatal Brain Development

Overview

Journal Methods Mol Biol

Specialty Molecular Biology

Date 2024 Nov 15

PMID 39546237

Authors

Martin G Frasch

Colin Wakefield

Ben Janoschek

Yael S Frank

Floyd Karp

Nicholas Reyes

Andre Desrochers

Mary C Wallingford

Marta C Antonelli

Gerlinde A S Metz

Affiliations

Soon will be listed here.

Abstract

Prenatal stress (PS) impacts early behavioral, neuroimmune, and cognitive development. Pregnant rat models have been very valuable in examining the mechanisms of such fetal programming. A pregnant sheep model of maternal stress offers the unique advantages of chronic in utero monitoring and manipulation. This chapter presents the techniques used to model single and multigenerational stress exposures and their pleiotropic effects on the offspring.

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