The Immune Modulatory Role of TIF1 Proteins

Overview

Journal Adv Exp Med Biol

Specialties Biology
General Medicine

Date 2024 Nov 15

PMID 39546137

Authors

Qingchen Zhu

Yichuan Xiao

Affiliations

Soon will be listed here.

Abstract

The function of immune cells is delicately regulated under a variety of molecular networks. Transcriptional intermediary factor 1 (TIF1) family proteins, consisting of TRIM24, TRIM28 and TRIM33, share a highly conserved RING domain that is essential for the regulation of protein ubiquitination functioning as E3 ubiquitin ligases. TIF1 family proteins are diversely expressed in different types of immune cells, and participate in the regulation of various of cellular functions including chromosome modification, DNA repair, tumor progression, and immunity. In this review, we summarized current studies on TIF1 family proteins' functions in the modulation of immune cell development, anti-infection immunity, cancer immunology, inflammation, and autoimmune diseases.

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