Blood Pressure Decreases in Overweight Elderly Individuals on Vitamin D: A Randomized Trial

Overview

Journal J Endocr Soc

Specialty Endocrinology

Date 2024 Nov 13

PMID 39534319

Authors

Maya Rahme

Laila Al-Shaar

Hani Tamim

Ghada El-Hajj Fuleihan

Affiliations

Soon will be listed here.

Abstract

Context: Evidence for a beneficial role of vitamin D on blood pressure (BP) outcomes is inconclusive.

Objective: This work aimed to investigate the effect of 2 doses of cholecalciferol (vitamin D) supplementation coadministered with calcium on systolic blood pressure (SBP) and diastolic blood pressure (DBP).

Methods: Exploratory analyses were conducted from a 1-year, multicenter, double-blind, randomized controlled trial (RCT). Total of 221 ambulatory older overweight individuals received calcium dose and oral vitamin D, at the equivalent of 600 IU/day or 3750 IU/day.

Results: SBP and DBP decreased significantly in the overall group, and in the high-dose group at 6 and 12 months. Similar trends were observed in the low-dose group, but did not achieve statistical significance. In participants with a body mass index (BMI) greater than 30, SBP decreased significantly in both treatment groups whereas DBP significantly decreased in the high-dose group only. In the subgroups of hypertensive participants (N = 143), there was a decrease in SBP and DBP at 6 and 12 months, with both vitamin D doses and independently of BMI levels. Using multivariate linear mixed models with random effects in the overall group of participants, SBP at 6 and 12 months was significantly predicted by BMI (β = .29; = .05) and by baseline SBP (β = .16; < .001), but not by vitamin D treatment dose.

Conclusion: Vitamin D and calcium decrease SBP and DBP in overweight older individuals, but more is not necessarily better. This effect is seen in individuals with BMI greater than 30, in hypertensive patients, and seems to be largely independent of dose.

Citing Articles

Vitamin D: Beyond Traditional Roles-Insights into Its Biochemical Pathways and Physiological Impacts.

Voiculescu V, Nelson Twakor A, Jerpelea N, Pantea Stoian A Nutrients. 2025; 17(5).

PMID: 40077673 PMC: 11902150. DOI: 10.3390/nu17050803.

Blood Pressure Decreases in Overweight Elderly Individuals on Vitamin D: A Randomized Trial.

Rahme M, Al-Shaar L, Tamim H, Fuleihan G J Endocr Soc. 2024; 8(12):bvae168.

PMID: 39534319 PMC: 11555685. DOI: 10.1210/jendso/bvae168.

References

Li Y, Kong J, Wei M, Chen Z, Liu S, Cao L . 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system. J Clin Invest. 2002; 110(2):229-38. PMC: 151055. DOI: 10.1172/JCI15219. View

Abderhalden L, Meyer S, Dawson-Hughes B, Orav E, Meyer U, De Godoi Rezende Costa Molino C . Effect of daily 2000 IU versus 800 IU vitamin D on blood pressure among adults age 60 years and older: a randomized clinical trial. Am J Clin Nutr. 2020; 112(3):527-537. DOI: 10.1093/ajcn/nqaa145. View

Tomson J, Hin H, Emberson J, Kurien R, Lay M, Cox J . Effects of Vitamin D on Blood Pressure, Arterial Stiffness, and Cardiac Function in Older People After 1 Year: BEST-D (Biochemical Efficacy and Safety Trial of Vitamin D). J Am Heart Assoc. 2017; 6(10). PMC: 5721827. DOI: 10.1161/JAHA.117.005707. View

Cormick G, Ciapponi A, Cafferata M, Cormick M, Belizan J . Calcium supplementation for prevention of primary hypertension. Cochrane Database Syst Rev. 2022; 1:CD010037. PMC: 8748265. DOI: 10.1002/14651858.CD010037.pub4. View

Farapti F, Fadilla C, Yogiswara N, Adriani M . Effects of vitamin D supplementation on 25(OH)D concentrations and blood pressure in the elderly: a systematic review and meta-analysis. F1000Res. 2020; 9:633. PMC: 7489275. DOI: 10.12688/f1000research.24623.3. View

Joukar F, Naghipour M, Hassanipour S, Salari A, Alizadeh A, Saeidi-Saedi H . Association of Serum Levels of Vitamin D with Blood Pressure Status in Northern Iranian Population: The PERSIAN Guilan Cohort Study (PGCS). Int J Gen Med. 2020; 13:99-104. PMC: 7073441. DOI: 10.2147/IJGM.S244472. View

Wu L, Sun D . Effects of calcium plus vitamin D supplementation on blood pressure: a systematic review and meta-analysis of randomized controlled trials. J Hum Hypertens. 2017; 31(9):547-554. DOI: 10.1038/jhh.2017.12. View

Wood A, Secombes K, Thies F, Aucott L, Black A, Mavroeidi A . Vitamin D3 supplementation has no effect on conventional cardiovascular risk factors: a parallel-group, double-blind, placebo-controlled RCT. J Clin Endocrinol Metab. 2012; 97(10):3557-68. DOI: 10.1210/jc.2012-2126. View

Burgaz A, Orsini N, Larsson S, Wolk A . Blood 25-hydroxyvitamin D concentration and hypertension: a meta-analysis. J Hypertens. 2010; 29(4):636-45. DOI: 10.1097/HJH.0b013e32834320f9. View

10.

Theiler-Schwetz V, Trummer C, Grubler M, Keppel M, Zittermann A, Tomaschitz A . Effects of Vitamin D Supplementation on 24-Hour Blood Pressure in Patients with Low 25-Hydroxyvitamin D Levels: A Randomized Controlled Trial. Nutrients. 2022; 14(7). PMC: 9003372. DOI: 10.3390/nu14071360. View

11.

Gepner A, Haller I, Krueger D, Korcarz C, Binkley N, Stein J . A randomized controlled trial of the effects of vitamin D supplementation on arterial stiffness and aortic blood pressure in Native American women. Atherosclerosis. 2015; 240(2):526-8. PMC: 4441558. DOI: 10.1016/j.atherosclerosis.2015.04.795. View

12.

Bouillon R, van Schoor N, Gielen E, Boonen S, Mathieu C, Vanderschueren D . Optimal vitamin D status: a critical analysis on the basis of evidence-based medicine. J Clin Endocrinol Metab. 2013; 98(8):E1283-304. DOI: 10.1210/jc.2013-1195. View

13.

Pilz S, Tomaschitz A, Ritz E, Pieber T . Vitamin D status and arterial hypertension: a systematic review. Nat Rev Cardiol. 2009; 6(10):621-30. DOI: 10.1038/nrcardio.2009.135. View

14.

Forman J, Scott J, Ng K, Drake B, Suarez E, Hayden D . Effect of vitamin D supplementation on blood pressure in blacks. Hypertension. 2013; 61(4):779-85. PMC: 3775458. DOI: 10.1161/HYPERTENSIONAHA.111.00659. View

15.

Pfeifer M, Begerow B, Minne H, Nachtigall D, Hansen C . Effects of a short-term vitamin D(3) and calcium supplementation on blood pressure and parathyroid hormone levels in elderly women. J Clin Endocrinol Metab. 2001; 86(4):1633-7. DOI: 10.1210/jcem.86.4.7393. View

16.

Jorde R, Sneve M, Torjesen P, Figenschau Y . No improvement in cardiovascular risk factors in overweight and obese subjects after supplementation with vitamin D3 for 1 year. J Intern Med. 2010; 267(5):462-72. DOI: 10.1111/j.1365-2796.2009.02181.x. View

17.

Scragg R, Slow S, Stewart A, Jennings L, Chambers S, Priest P . Long-term high-dose vitamin D3 supplementation and blood pressure in healthy adults: a randomized controlled trial. Hypertension. 2014; 64(4):725-30. DOI: 10.1161/HYPERTENSIONAHA.114.03466. View

18.

Vimaleswaran K, Cavadino A, Berry D, Jorde R, Dieffenbach A, Lu C . Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study. Lancet Diabetes Endocrinol. 2014; 2(9):719-29. PMC: 4582411. DOI: 10.1016/S2213-8587(14)70113-5. View

19.

van Mierlo L, Arends L, Streppel M, Zeegers M, Kok F, Grobbee D . Blood pressure response to calcium supplementation: a meta-analysis of randomized controlled trials. J Hum Hypertens. 2006; 20(8):571-80. DOI: 10.1038/sj.jhh.1002038. View

20.

Witham M, Price R, Struthers A, Donnan P, Messow C, Ford I . Cholecalciferol treatment to reduce blood pressure in older patients with isolated systolic hypertension: the VitDISH randomized controlled trial. JAMA Intern Med. 2013; 173(18):1672-9. DOI: 10.1001/jamainternmed.2013.9043. View