Survivin Promotes Stem Cell Competence for Skin Cancer Initiation

Overview

Journal Cancer Discov

Specialty Oncology

Date 2024 Nov 11

PMID 39526566

Authors

Sara Canato

Rahul Sarate

Sofia Carvalho-Marques

Raquel Maia Soares

Yura Song

Sara Monteiro-Ferreira

Pauline Vieugue

Melanie Liagre

Giancarlo Grossi

Erik Cardoso

Christine Dubois

Edward M Conway

Silvia Schenone

Adriana Sanchez-Danes

Cedric Blanpain

Affiliations

Soon will be listed here.

Abstract

This study identifies Survivin as a key regulator of the different ability of SCs and Ps to initiate skin cancer. Survivin expression in oncogene-targeted SCs is essential for their survival and self-renewal and to prevent their differentiation and apoptosis, allowing SCs and not Ps to initiate skin cancer.

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