Baicalein Suppresses Inflammation and Attenuates Acute Lung Injury by Inhibiting Glycolysis Via HIF‑1α Signaling

Overview

Journal Mol Med Rep

Specialty Molecular Biology

Date 2024 Nov 8

PMID 39513601

Authors

Zhongyou Liu

Xiaona Zheng

Ning Li

Zongyao Wang

Affiliations

Soon will be listed here.

Abstract

Baicalein, a flavonoid monomer compound isolated from the dried root of the traditional Chinese herb , has several pharmacological activities, such as anti‑inflammatory, anti‑angiogenic, antitumor, antimicrobial and antiviral properties. Acute lung injury (ALI) is characterized by injury of the alveolar epithelium and capillary endothelium, which results in decreased lung volume, decreased lung compliance, ventilation/perfusion mismatch, intrapulmonary edema, alveolar edema and even acute hypoxemic respiratory failure. The present study aimed to investigate the effects of baicalein on lung injury and inflammation. Bioinformatics analysis using network pharmacology predicted that the hypoxia inducible factor‑1α (HIF‑1α) and glycolysis signaling pathways were involved in the mechanism underlying the therapeutic effects of baicalein. Further and experiments, such as immunohistochemistry, immunofluorescence and PCR, verified that baicalein could inhibit HIF‑1α signaling, thus suppressing glycolysis, and improving inflammatory responses and ALI. Taken together, the results of the present study suggested that the anti‑inflammatory effects of baicalein on treating ALI were associated with its ability to suppress glycolysis via the HIF‑1α signaling pathway.

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