Diffusion-derived Intravoxel-incoherent Motion Anisotropy Relates to CSF and Blood Flow

Overview

Journal Magn Reson Med

Publisher Wiley

Specialty Radiology

Date 2024 Nov 6

PMID 39503237

Authors

Paulien H M Voorter

Jacobus F A Jansen

Merel M van der Thiel

Maud van Dinther

Alida A Postma

Robert J van Oostenbrugge

Oliver J Gurney-Champion

Gerhard S Drenthen

Walter H Backes

Affiliations

Soon will be listed here.

Abstract

Methods: Multi-b-value diffusion MRI was acquired in 32 gradient directions for 11 healthy volunteers, and in six directions for 29 patients with cSVD and 14 controls at 3 T. A physics-informed neural network was used to estimate intravoxel incoherent motion (IVIM)-DTI model parameters, including the parenchymal slow diffusion (D-)tensor and the pseudo-diffusion (D*)-tensor, from which the fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were derived. Comparisons of D*-tensor metrics were made between lateral, third, and fourth ventricles and between the middle cerebral arteries and superior sagittal sinus. Group differences in D*-tensor metrics in normal-appearing white matter were analyzed using multivariable linear regression, correcting for age and sex.

Results: D*-anisotropy aligned well with CSF flow and arterial blood flow. FA(D*), MD(D*), AD(D*), and RD(D*) were highest in the third, moderate in the fourth, and lowest in the lateral ventricles. The arteries showed higher MD(D*), AD(D*), and RD(D*) than the sagittal sinus. Higher FA(D*) in the normal-appearing white matter was related to cSVD diagnosis and older age, suggesting microvascular architecture alterations.

Conclusion: Multi-b-value, multi-directional diffusion analysis using the IVIM-DTI model enables assessment of the cerebral microstructure, fluid flow, and microvascular architecture, providing information on neurodegeneration, glymphatic waste clearance, and the vasculature in one measurement.

Citing Articles

Diffusion-derived intravoxel-incoherent motion anisotropy relates to CSF and blood flow.

Voorter P, Jansen J, van der Thiel M, van Dinther M, Postma A, van Oostenbrugge R Magn Reson Med. 2024; 93(3):930-941.

PMID: 39503237 PMC: 11680721. DOI: 10.1002/mrm.30294.

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