Regional Mechanical Dyssynchrony and Shortened Systole Are Present in People with Takotsubo Syndrome

Overview

Journal Commun Med (Lond)

Publisher Nature Portfolio

Specialty General Medicine

Date 2024 Nov 2

PMID 39487225

Authors

Jan-Christian Reil

Vasco Sequeira

Gert-Hinrich Reil

Paul Steendijk

Christoph Maack

Thomas Fink

Elias Rawish

Ingo Eitel

Thomas Stiermaier

Affiliations

Soon will be listed here.

Abstract

Background: Takotsubo syndrome is characterized by transient regional systolic dysfunction, left ventricular (LV) dilatation, and edema, often occurring without obstructive coronary artery disease. The mechanisms underlying this stress-induced condition, especially the role of mechanical dyssynchrony in affecting systolic function, remain poorly understood.

Methods: In our study, we evaluated global LV function and mechanical dyssynchrony in 24 Takotsubo patients compared to 20 controls by analyzing pressure-volume loops and time-varying elastance. Additionally, we monitored changes in LV segmental volume and internal flow.

Results: Here we show a significant reduction in global myocardial contractility and pronounced mechanical dyssynchrony in Takotsubo syndrome, particularly in the mid and apical LV segments, without disturbances in electrical conduction.

Conclusions: Our findings reveal substantial mechanical dyssynchrony in Takotsubo patients, characterized by increased internal flow and a shortened systolic ejection time. This indicates a mechanical basis for the inefficient LV function in Takotsubo syndrome, independent of electrical conduction abnormalities.

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