Effect of Neutrophils on Tumor Immunity and Immunotherapy Resistance with Underlying Mechanisms

Overview

Journal Cancer Commun (Lond)

Publisher Wiley

Specialty Oncology

Date 2024 Nov 1

PMID 39485719

Authors

Jiali Yao

Linlin Ji

Guang Wang

Jin Ding

Affiliations

Soon will be listed here.

Abstract

Neutrophils are key mediators of the immune response and play essential roles in the development of tumors and immune evasion. Emerging studies indicate that neutrophils also play a critical role in the immunotherapy resistance in cancer. In this review, firstly, we summarize the novel classification and phenotypes of neutrophils and describe the regulatory relationships between neutrophils and tumor metabolism, flora microecology, neuroendocrine and tumor therapy from a new perspective. Secondly, we review the mechanisms by which neutrophils affect drug resistance in tumor immunotherapy from the aspects of the immune microenvironment, tumor antigens, and epigenetics. Finally, we propose several promising strategies for overcoming tumor immunotherapy resistance by targeting neutrophils and provide new research ideas in this area.

Citing Articles

Effect of neutrophils on tumor immunity and immunotherapy resistance with underlying mechanisms.

Yao J, Ji L, Wang G, Ding J Cancer Commun (Lond). 2024; 45(1):15-42.

PMID: 39485719 PMC: 11758154. DOI: 10.1002/cac2.12613.

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