Algal Polysaccharides: New Perspectives for the Treatment of Basal Ganglia Neurodegenerative Diseases

Overview

Journal Front Neuroanat

Date 2024 Oct 31

PMID 39479366

Authors

Alessandra Marinho Miranda Lucena

Eudes Euler de Souza Lucena

Sebastiao Pacheco Duque Neto

Leonardo Thiago Duarte Barreto Nobre

Hugo Alexandre Oliveira Rocha

Rafael Barros Gomes Camara

Affiliations

Soon will be listed here.

Abstract

The objective of this review was to verify the therapeutic effect of polysaccharides derived from algae in neurodegenerative disease models involving the basal ganglia. To achieve this goal, a literature search was conducted in PubMed, Science Direct, Scopus, Web of Science, Embase, and Google Scholar databases. The descriptors "neuroprotective or neural regenerative or immunomodulatory activity or neuroprotection," "polysaccharide or carbohydrate or carbohydrate polymers," "marine algae or seaweed," and "basal ganglia" according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) methodology were used. This methodology involved the steps of searching, pre-selection, and inclusion of articles. A total of 737 records were identified. Following the data analysis, 698 studies were excluded, resulting in a final sample of 8 studies. Species such as , , , , , and have demonstrated significant neuroprotective effects. This review suggests that polysaccharides derived from marine algae possess therapeutic potential for neuroprotection, modulation of inflammation, and amelioration of functional deficits. Their use in neurodegenerative disease models warrants further consideration.

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