Correlations Between Patient-specific Parameters and Dosimetric Indices for Personalized Breast Cancer Radiotherapy

Overview

Journal Sci Rep

Specialty Science

Date 2024 Oct 31

PMID 39478060

Authors

Ioana-Claudia Costin

Loredana G Marcu

Affiliations

Soon will be listed here.

Abstract

Treatment planning parameters in radiotherapy are key elements that dictate the success of treatment outcome. While some parameters are commonly evaluated irrespective of cancer type, others are site-dependent and strongly patient specific. Given the critical influence of planning parameters on personalized therapy, the aim of this study was to evaluate the correlations between the dosimetric indices (conformity, homogeneity and mismatch indices) related to tumor coverage and the patient-specific parameters which encompass parameters pertaining to organs at risk (widths and lengths of heart and ipsilateral lung included in treatment fields, mean/maximum doses to heart, ipsilateral lung, left anterior descending aorta and contralateral breast) and tumor volume. Forty breast cancer patients were divided into two groups according to tumor location: twenty with left-sided (group A) and twenty with right-sided breast cancer (group B). Conformal (3DCRT), intensity modulated (IMRT) and volumetric arc modulated (VMAT) radiotherapy techniques were used for plan creation. Moderate to strong correlations were found for ipsilateral lung parameters for both groups of patients regardless of the treatment technique. Moderate to strong correlations were found for heart parameters in group A patients, while no correlations were observed in group B. The mismatch index presented moderate to strong correlations with tumor volume for all treatment techniques (r = -0.861 3DCRT, r = -0.556 IMRT, r = -0.533 VMAT) particularly in group A. The evaluated correlations indicate the role of dosimetric indices in personalized treatment planning.

References

Xie Y, Bourgeois D, Guo B, Zhang R . Comparison of conventional and advanced radiotherapy techniques for left-sided breast cancer after breast conserving surgery. Med Dosim. 2020; 45(4):e9-e16. PMC: 7609481. DOI: 10.1016/j.meddos.2020.05.004. View

Schoepen M, Speleers B, De Neve W, Vakaet V, Deseyne P, Paelinck L . Four irradiation and three positioning techniques for whole-breast radiotherapy: Is sophisticated always better?. J Appl Clin Med Phys. 2022; 23(11):e13720. PMC: 9680580. DOI: 10.1002/acm2.13720. View

Rahimy E, Hong J, Gross C, Hu X, Soulos P, Shafman T . Increased Number of Beam Angles Is Associated With Higher Cardiac Dose in Adjuvant Fixed Gantry Intensity Modulated Radiation Therapy of Left-Sided Breast Cancer. Int J Radiat Oncol Biol Phys. 2017; 99(5):1137-1145. DOI: 10.1016/j.ijrobp.2017.06.2451. View

Bisello S, Cilla S, Benini A, Cardano R, Nguyen N, Deodato F . Dose-Volume Constraints fOr oRganS At risk In Radiotherapy (CORSAIR): An "All-in-One" Multicenter-Multidisciplinary Practical Summary. Curr Oncol. 2022; 29(10):7021-7050. PMC: 9600677. DOI: 10.3390/curroncol29100552. View

Gocer G, Ozer E . Effect of radiotherapy on coronary arteries and heart in breast-conserving surgery: a dosimetric analysis. Radiol Oncol. 2020; 54(1):128-134. PMC: 7087428. DOI: 10.2478/raon-2020-0013. View

Bray F, Ferlay J, Soerjomataram I, Siegel R, Torre L, Jemal A . Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018; 68(6):394-424. DOI: 10.3322/caac.21492. View

Xu H, Hatcher G . Treatment planning study of Volumetric Modulated Arc Therapy and three dimensional field-in-field techniques for left chest-wall cancers with regional lymph nodes. Rep Pract Oncol Radiother. 2016; 21(6):517-524. PMC: 5036511. DOI: 10.1016/j.rpor.2016.07.005. View

Balaji K, Subramanian B, Yadav P, Anu Radha C, Ramasubramanian V . Radiation therapy for breast cancer: Literature review. Med Dosim. 2016; 41(3):253-7. DOI: 10.1016/j.meddos.2016.06.005. View

Costin I, Marcu L . Factors impacting on patient setup analysis and error management during breast cancer radiotherapy. Crit Rev Oncol Hematol. 2022; 178:103798. DOI: 10.1016/j.critrevonc.2022.103798. View

10.

Azharuddin S, Kumar P, S N, Chauhan A, Kumar P, Nigam J . Comparison of Dosimetric Parameters and Clinical Outcomes in Inversely Planned Intensity-Modulated Radiotherapy (IMRT) and Field-in-Field Forward Planned IMRT for the Treatment of Breast Cancer. Cureus. 2022; 14(7):e26692. PMC: 9358132. DOI: 10.7759/cureus.26692. View

11.

Xin X, Li J, Zhao Y, Wang P, Tang B, Yao X . Retrospective Study on Left-Sided Breast Radiotherapy: Dosimetric Results and Correlation with Physical Factors for Free Breathing and Breath Hold Irradiation Techniques. Technol Cancer Res Treat. 2021; 20:15330338211062429. PMC: 8646776. DOI: 10.1177/15330338211062429. View

12.

Eskandari A, Nasseri S, Gholamhosseinian H, Hosseini S, Keikhai Farzaneh M, Keramati A . Evaluation of the heart and lung dosimetric parameters in deep inspiration breath hold using 3D Slicer. Radiat Oncol J. 2020; 38(1):68-76. PMC: 7113148. DOI: 10.3857/roj.2019.00654. View

13.

Garg A, Kumar P . Dosimetric Comparison of the Heart and Left Anterior Descending Artery in Patients With Left Breast Cancer Treated With Three-Dimensional Conformal and Intensity-Modulated Radiotherapy. Cureus. 2022; 14(1):e21108. PMC: 8750670. DOI: 10.7759/cureus.21108. View

14.

Wang Y, Ni L, Ying S, Xu Y, Chen W, Liu Y . Individualized estimates of intensity-modulated radiotherapy plans after breast conservation surgery for left-sided breast cancer. World J Surg Oncol. 2023; 21(1):59. PMC: 9948370. DOI: 10.1186/s12957-023-02936-8. View

15.

Xie Y, Hu T, Chen R, Chang H, Wang Q, Cheng J . Predicting acute radiation dermatitis in breast cancer: a prospective cohort study. BMC Cancer. 2023; 23(1):537. PMC: 10262502. DOI: 10.1186/s12885-023-10821-6. View

16.

Liu Y, Chang H, Lin H, Lu C, Lai L . Dosimetric Comparison of Intensity-Modulated Radiotherapy, Volumetric Modulated Arc Therapy and Hybrid Three-Dimensional Conformal Radiotherapy/Intensity-Modulated Radiotherapy Techniques for Right Breast Cancer. J Clin Med. 2020; 9(12). PMC: 7760558. DOI: 10.3390/jcm9123884. View

17.

Kundrat P, Remmele J, Rennau H, Sebb S, Simonetto C, Eidemuller M . Minimum breast distance largely explains individual variability in doses to contralateral breast from breast-cancer radiotherapy. Radiother Oncol. 2018; 131:186-191. DOI: 10.1016/j.radonc.2018.08.022. View

18.

Johansen S, Cozzi L, Olsen D . A planning comparison of dose patterns in organs at risk and predicted risk for radiation induced malignancy in the contralateral breast following radiation therapy of primary breast using conventional, IMRT and volumetric modulated arc treatment.... Acta Oncol. 2009; 48(4):495-503. DOI: 10.1080/02841860802657227. View

19.

Alaimo R, Ippolito E, Falconi R, Perrone Congedi F, Sciommari C, Silipigni S . Breast Volume Is a Predictor of Higher Heart Dose in Whole-Breast Supine Free-Breathing Volumetric-Modulated Arc Therapy Planning. Curr Oncol. 2023; 30(12):10530-10538. PMC: 10742666. DOI: 10.3390/curroncol30120768. View

20.

Fadavi P, Mehrabian A, Salmanian S, Mahdavi S, Yousefi Diba A, Javadinia S . The Relationship between Lung and Heart Two-Dimensional Parameters and Three-Dimensional Dose-Volume Data in Adjuvant Radiotherapy for Breast Cancer. Med J Islam Repub Iran. 2022; 36:16. PMC: 9386768. DOI: 10.47176/mjiri.36.16. View