Reinvesting the Cellular Properties of Human Amniotic Epithelial Cells and Their Therapeutic Innovations

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2024 Oct 30

PMID 39474414

Authors

Jing Yang

Yuefeng Lu

Jinping Zhao

Yi Luo

Wangping Hao

Wencheng Zhang

Zhiying He

Affiliations

Soon will be listed here.

Abstract

Human amniotic epithelial cells (hAECs) have shown promising therapeutic effects in numerous studies on various diseases due to their properties such as low immunogenicity, immunomodulation, paracrine effect, and no teratoma formation . Nevertheless, there are still many problems in archiving the large-scale clinical application of hAECs, ranging from the vague definition of cell properties to the lack of clarification of the motion of actions in cell therapies, additionally, to the gap between cell quantities with limited proliferation capacity. This review provides a detailed overview of hAECs in the aspects of the lineage development of amniotic epithelial cell, cell characteristics and functional roles, cell cultivation and expansion systems, as well as their current status and limitations in clinical applications. This review also discusses the advantages, limitations and feasibility of hAECs, and anticipates their prospects as cell therapy products, with the aim of further promoting their clinical applications.

References

Liu J, Hua R, Gong Z, Shang B, Huang Y, Guo L . Human amniotic epithelial cells inhibit CD4+ T cell activation in acute kidney injury patients by influencing the miR-101-c-Rel-IL-2 pathway. Mol Immunol. 2016; 81:76-84. DOI: 10.1016/j.molimm.2016.11.019. View

Johnson M, McConnell J . Lineage allocation and cell polarity during mouse embryogenesis. Semin Cell Dev Biol. 2004; 15(5):583-97. DOI: 10.1016/j.semcdb.2004.04.002. View

Zhang Q, Lai D . Application of human amniotic epithelial cells in regenerative medicine: a systematic review. Stem Cell Res Ther. 2020; 11(1):439. PMC: 7559178. DOI: 10.1186/s13287-020-01951-w. View

Wu Z, Hui G, Lu Y, Wu X, Guo L . Transplantation of human amniotic epithelial cells improves hindlimb function in rats with spinal cord injury. Chin Med J (Engl). 2007; 119(24):2101-7. View

Gopalakrishna A, Karim K . Fetal membranes and placentation in Chiroptera. J Reprod Fertil. 1979; 56(1):417-29. DOI: 10.1530/jrf.0.0560417. View

Liu Q, Li J, Zhang X, Liu Y, Liu Q, Xiao L . Human amniotic mesenchymal stem cells inhibit hepatocellular carcinoma in tumour-bearing mice. J Cell Mol Med. 2020; 24(18):10525-10541. PMC: 7521292. DOI: 10.1111/jcmm.15668. View

Sutherland A, Speed T, Calarco P . Inner cell allocation in the mouse morula: the role of oriented division during fourth cleavage. Dev Biol. 1990; 137(1):13-25. DOI: 10.1016/0012-1606(90)90003-2. View

Shao Y, Taniguchi K, Gurdziel K, Townshend R, Xue X, Aw Yong K . Self-organized amniogenesis by human pluripotent stem cells in a biomimetic implantation-like niche. Nat Mater. 2016; 16(4):419-425. PMC: 5374007. DOI: 10.1038/nmat4829. View

Adinolfi M, Akle C, McColl I, Fensom A, Tansley L, Connolly P . Expression of HLA antigens, beta 2-microglobulin and enzymes by human amniotic epithelial cells. Nature. 1982; 295(5847):325-7. DOI: 10.1038/295325a0. View

10.

Naeem A, Choudhry M, Kroemer A, Wahnschafft S, Cui W, Albanese C . Expansion of human amniotic epithelial cells using condition cell reprogramming technology. Hum Cell. 2022; 36(2):602-611. PMC: 9947022. DOI: 10.1007/s13577-022-00849-4. View

11.

Zhang Y, Ouyang X, You S, Zou H, Shao X, Zhang G . Effect of human amniotic epithelial cells on ovarian function, fertility and ovarian reserve in primary ovarian insufficiency rats and analysis of underlying mechanisms by mRNA sequencing. Am J Transl Res. 2020; 12(7):3234-3254. PMC: 7407690. View

12.

Zhu Y, Wang H, Yin F, Guo Y, Li F, Gao D . Amnion-on-a-chip: modeling human amniotic development in mid-gestation from pluripotent stem cells. Lab Chip. 2020; 20(17):3258-3268. DOI: 10.1039/d0lc00268b. View

13.

Motedayyen H, Esmaeil N, Tajik N, Khadem F, Ghotloo S, Khani B . Method and key points for isolation of human amniotic epithelial cells with high yield, viability and purity. BMC Res Notes. 2017; 10(1):552. PMC: 5669002. DOI: 10.1186/s13104-017-2880-6. View

14.

Miki T, Lehmann T, Cai H, Stolz D, Strom S . Stem cell characteristics of amniotic epithelial cells. Stem Cells. 2005; 23(10):1549-59. DOI: 10.1634/stemcells.2004-0357. View

15.

Branski L, Herndon D, Celis M, Norbury W, Masters O, Jeschke M . Amnion in the treatment of pediatric partial-thickness facial burns. Burns. 2007; 34(3):393-9. DOI: 10.1016/j.burns.2007.06.007. View

16.

Liu Y, Vaghjiani V, Tee J, To K, Cui P, Oh D . Amniotic epithelial cells from the human placenta potently suppress a mouse model of multiple sclerosis. PLoS One. 2012; 7(4):e35758. PMC: 3338525. DOI: 10.1371/journal.pone.0035758. View

17.

Bjorklund G, Peana M, Maes M, Dadar M, Severin B . The glutathione system in Parkinson's disease and its progression. Neurosci Biobehav Rev. 2020; 120:470-478. DOI: 10.1016/j.neubiorev.2020.10.004. View

18.

Ren Y, Chen Y, Zheng X, Wang H, Kang X, Tang J . Human amniotic epithelial cells ameliorate kidney damage in ischemia-reperfusion mouse model of acute kidney injury. Stem Cell Res Ther. 2020; 11(1):410. PMC: 7510147. DOI: 10.1186/s13287-020-01917-y. View

19.

Gramignoli R, Srinivasan R, Kannisto K, Strom S . Isolation of Human Amnion Epithelial Cells According to Current Good Manufacturing Procedures. Curr Protoc Stem Cell Biol. 2016; 37:1E.10.1-1E.10.13. DOI: 10.1002/cpsc.2. View

20.

Murphy S, Rosli S, Acharya R, Mathias L, Lim R, Wallace E . Amnion epithelial cell isolation and characterization for clinical use. Curr Protoc Stem Cell Biol. 2010; Chapter 1:Unit 1E.6. DOI: 10.1002/9780470151808.sc01e06s13. View