Association of Human Leucocyte Antigen Loci with Vaccine-induced Immune Thrombotic Thrombocytopenia: Potential Role of the Interaction Between Platelet Factor 4-derived Peptides and MHC-II

Overview

Journal Br J Haematol

Specialty Hematology

Date 2024 Oct 27

PMID 39462764

Authors

Eleonora Petito

Loredana Bury

Lilian Antunes Heck

Brooke Sadler

Erica De Candia

Gian Marco Podda

Anna Falanga

Lucia Stefanini

Andrea Boccatonda

Patrizia Sciancalepore

Igor Florio

Egidio Imbalzano

Rossella Marcucci

Patrizia Noris

Marta Panella

Rita Carlotta Santoro

Maria Costanza Turi

Gaetano Vaudo

Jorge Di Paola

Matthew T Rondina

Paolo Gresele

Affiliations

Soon will be listed here.

Abstract

No risk factors have been identified for vaccine-induced immune thrombotic thrombocytopenia (VITT) so far. The aim of this study was to identify human leucocyte antigen (HLA) alleles potentially associated with VITT susceptibility. Specific HLA class II alleles were detected with significantly higher frequency in VITT patients compared with Italian controls: DPB1*17:01, DQA1*05:01, and DRB1*11:04. In silico analysis revealed increased affinity of DRB1*11:04 for a platelet factor 4 (PF4)-derived peptide, ITSLEVIKA, that contains two amino acids present in the specific binding site of anti-PF4 antibodies from VITT patients. Our findings show for the first time a genetic predisposition to developing anti-PF4 antibodies in response to Ad-vector vaccines.

Citing Articles

Association of human leucocyte antigen loci with vaccine-induced immune thrombotic thrombocytopenia: Potential role of the interaction between platelet factor 4-derived peptides and MHC-II.

Petito E, Bury L, Antunes Heck L, Sadler B, De Candia E, Podda G Br J Haematol. 2024; 206(1):290-295.

PMID: 39462764 PMC: 11739772. DOI: 10.1111/bjh.19838.

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