A Systematic Review and Comprehensive Analysis of Gene Prevalence in Bacterial Isolates in Arab Countries

Overview

Journal Antibiotics (Basel)

Specialty Pharmacology

Date 2024 Oct 25

PMID 39452224

Authors

Mouayad Zuheir Bakleh

Muhammad Kohailan

Muhammad Marwan

Abdallah Alhaj Sulaiman

Affiliations

Soon will be listed here.

Abstract

Background: The resurgence of colistin has become critical in combating multidrug-resistant Gram-negative bacteria. However, the emergence of mobilized colistin resistance () genes presents a crucial global challenge, particularly in the Arab world, which includes regions with unique conditions and ongoing conflicts in some parts.

Methods: To address this issue, a systematic review was conducted using multiple databases, including Cochrane, PubMed, Scopus, Web of Science, and Arab World Research Source.

Results: A total of 153 studies were included, revealing substantial heterogeneity in the prevalence of genes across 15 Arab countries, with notable findings indicating that Egypt and Lebanon reported the highest number of cases. The analysis indicated that the most prevalent sequence types were ST10, ST101, and ST1011, all of which are strains linked to significant levels of colistin resistance and multiple antimicrobial resistance profiles.

Conclusions: By analyzing the diverse findings from different Arab countries, this review lays a critical foundation for future research and highlights the necessity for enhanced surveillance and targeted interventions to address the looming threat of colistin resistance in the region.

Systematic Review Registration: PROSPERO CRD42024584379.

Citing Articles

A Systematic Review and Comprehensive Analysis of Gene Prevalence in Bacterial Isolates in Arab Countries.

Bakleh M, Kohailan M, Marwan M, Alhaj Sulaiman A Antibiotics (Basel). 2024; 13(10).

PMID: 39452224 PMC: 11505126. DOI: 10.3390/antibiotics13100958.

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