Carcinoembryonic Antigen-related Cell Adhesion Molecule 1 in Cancer: Blessing or Curse?

Overview

Journal Eur J Clin Invest

Publisher Wiley

Specialty General Medicine

Date 2024 Oct 25

PMID 39451132

Authors

Lisa Gotz

Uwe Rueckschloss

Sonia M Najjar

Suleyman Ergun

Florian Kleefeldt

Affiliations

Soon will be listed here.

Abstract

The Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1, also CD66a), a transmembrane glycoprotein of the immunoglobulin superfamily, is a pivotal mediator of various physiological and pathological processes, including oncologic disorders. However, its precise role in tumorigenicity is contradictory discussed by several clinical studies. This review aims to elucidate the clinical significance of CEACAM1 in different cancer entities focusing on tumour formation, progression and metastasis as well as on CEACAM1-mediated treatment resistance. Furthermore, we discuss the contribution of CEACAM1 to cancer immunity and modulation of the inflammatory microenvironment and finally provide a comprehensive review of treatment regimens targeting this molecule.

Citing Articles

CEACAM1 in vascular homeostasis and inflammation.

Gotz L, Rueckschloss U, Ergun S, Kleefeldt F Eur J Clin Invest. 2024; 54 Suppl 2:e14345.

PMID: 39674877 PMC: 11646292. DOI: 10.1111/eci.14345.

Carcinoembryonic antigen-related cell adhesion molecule 1 in cancer: Blessing or curse?.

Gotz L, Rueckschloss U, Najjar S, Ergun S, Kleefeldt F Eur J Clin Invest. 2024; 54 Suppl 2:e14337.

PMID: 39451132 PMC: 11646294. DOI: 10.1111/eci.14337.

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