Investigating the Effects of a Daily Multidisciplinary Intensive Outpatient Rehabilitation Program on Innovative Biomarkers in People with Parkinson's Disease: Study Protocol for a Phase III Randomized Controlled Clinical Trial

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2024 Oct 23

PMID 39441873

Authors

Francesca Lea Saibene

Cristina Agliardi

Anna Salvatore

Pietro Arcuri

Anna Castagna

Silvia Gobbo

Federico Merlo

Thomas Bowman

Denise Anastasi

Chiara Pagliari

Elisabetta Farina

Margherita Alberoni

Elena Calabrese

Francesca La Rosa

Chiara Arienti

Marina Saresella

Franca Rosa Guerini

Davide Cattaneo

Francesca Baglio

Mario Clerici

Jorge Navarro

Mario Meloni

Affiliations

Soon will be listed here.

Abstract

Background: To date, there has been no medication that has prevented the progression of Parkinson's disease (PD). Many benefits of intensive and multidisciplinary rehabilitation program for PD are supported by clinical, epidemiological, and experimental data. The main question is whether high-intensity motor and cognitive exercises have an effect on the disease's biological mechanisms.

Objective: This study protocol is a Randomized Controlled Trial (RCT) designed to determine the efficacy of an experimental, intensive, and multidisciplinary treatment in comparison to a home-based self-treatment in improving biomolecular and functional parameters in PD.

Methods: A total of 72 participants will be randomly allocated to two different groups, experimental (n = 36) and control group (n = 36). The rehabilitation program will last 6 consecutive weeks and will involve the execution of a total of 30 sessions, one for each day of the week from Monday to Friday. Participants allocated to the control group will carry out a home-based self-treatment program that includes muscle-stretching and active mobilization exercises for 40'/day for 6 consecutive weeks. The primary outcome measure is the effects of both treatments on a new set of molecular biomarkers such as oligomeric alpha-synuclein and neurotrophic factors measured in peripheral neural derived extracellular vesicles (NDEVs). Secondary outcomes will include changes of motor and non-motor symptoms, balance and gait performance and cognitive functioning. This RCT has been registered as "Intensive Multidisciplinary Rehabilitation and Biomarkers in Parkinson's Disease" on 30 May, 2022 to ClinicalTrials.gov with the Study ID number: NCT05452655.

Discussion: This rehabilitation program is believed to be crucial in modifying biomolecular and functional parameters in people with PD. We expect that this study will provide additional evidence to understand the impact of an aerobic and intensive rehabilitation program on brain plasticity in patients with PD.

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