Neurotrophic Factors in Parkinson's Disease Are Regulated by Exercise: Evidence-based Practice

Overview

Journal J Neurol Sci

Publisher Elsevier

Specialty Neurology

Date 2016 Mar 23

PMID 27000212

Citations 29

Authors

Paula Grazielle Chaves da Silva

Daniel Desiderio Domingues

Litia Alves de Carvalho

Silvana Allodi

Clynton Lourenco Correa

Affiliations

Soon will be listed here.

Abstract

We carried out a qualitative review of the literature on the influence of forced or voluntary exercise in Parkinson's Disease (PD)-induced animals, to better understand neural mechanisms and the role of neurotrophic factors (NFs) involved in the improvement of motor behavior. A few studies indicated that forced or voluntary exercise may promote neuroprotection, through upregulation of NF expression, against toxicity of drugs that simulate PD. Forced training, such as treadmill exercise and forced-limb use, adopted in most studies, in addition to voluntary exercise on a running wheel are suitable methods for NFs upregulation.

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