Non Invasive Preimplantation Testing for Aneuploidies in Assisted Reproduction: A SWOT Analysis

Overview

Journal Reprod Sci

Publisher Springer

Specialty Reproductive Medicine

Date 2024 Oct 21

PMID 39433699

Authors

Elena Carrillo de Albornoz

Jose Antonio Dominguez Arroyo

Yosu Franco Iriarte

Xavier Vendrell

Veronica Martinez Vidal

Maria Carrera Roig

Affiliations

Soon will be listed here.

Abstract

The implementation of non-invasive PGT-A offers a new strategy to genetically assess the preimplantation embryo and to enhance IVF results. The extraction of DNA from the embryo culture medium has been sufficiently demonstrated, and the ability to obtain chromosomal information as a result is particularly interesting. As morphological criteria have proven to have a weak correlation with embryo ploidy status, this technique emerges as a promising alternative for embryo selection. It also appears reasonable that avoiding biopsy may enhance further embryo development. However, there are growing concerns regarding several aspects of this technique, such as the origin of this cell free DNA, the degree of representativeness of the whole embryo, the need for extended culture or the absence of standardized protocols. Despite the published data on good prognosis couples are promising, niPGT-A is yet to be considered a substitute for trophectoderm biopsy. The current SWOT analysis aims to summarize both resolved and unresolved issues, as well as limiting aspects of niPGT-A.

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