Effects of Daily Almond Consumption on Glycaemia in Adults with Elevated Risk for Diabetes: a Randomised Controlled Trial

Overview

Journal Br J Nutr

Specialty Nutritional Sciences

Date 2024 Oct 21

PMID 39431574

Authors

Li-Chu Huang

Gregory C Henderson

Richard D Mattes

Affiliations

Soon will be listed here.

Abstract

The purpose of this study was to examine the potential for sustained almond consumption to reduce HbA1c concentrations among individuals with elevated values. A 16-week randomised, parallel-arm, controlled trial was conducted. Eighty-one adults with elevated HbA1c concentrations (> 5·7 %) were randomly assigned to incorporate 2 oz of raw almonds (A: 39) or energy-matched snacks (C: 42) into their daily diets. Body weight, body composition, plasma lipids, HbA1c, plasma vitamin E, glycaemia (by meal tolerance test and continuous glucose monitoring), dietary intake and hedonic responses to test foods were measured at stipulated time points. Participants consuming almonds ingested 253 kcal/d more than participants in the control group ( = 0·02), but this did not result in a significant difference in body weight. No statistically significant differences were observed in HbA1c concentrations, blood chemistries, body composition or glycaemia over time or between groups. However, Healthy Eating Index scores improved within the almond group as compared with the control group ( < 0·001). Additionally, the hedonic rating of almonds within the almond group did not decline as markedly as the control group's reduced liking of the pretzel snack. Alpha-tocopherol increased significantly, and gamma tocopherol tended to decrease in the almond group, indicating compliance with the dietary intervention. Overall, daily ingestion of 2 oz of raw almonds in a self-selected diet for 16 weeks did not alter short-term or longer-term glycaemia or HbA1c concentrations in adults with elevated HbA1c concentrations, but they were well-tolerated hedonically and improved diet quality without promoting weight gain.

References

Brown R, Ware L, Gray A, Chisholm A, Tey S . Snacking on Almonds Lowers Glycaemia and Energy Intake Compared to a Popular High-Carbohydrate Snack Food: An Acute Randomised Crossover Study. Int J Environ Res Public Health. 2021; 18(20). PMC: 8535760. DOI: 10.3390/ijerph182010989. View

Beavers K, Case L, Blackwell C, Katula J, Goff Jr D, Vitolins M . Effects of weight regain following intentional weight loss on glucoregulatory function in overweight and obese adults with pre-diabetes. Obes Res Clin Pract. 2014; 9(3):266-73. PMC: 4385513. DOI: 10.1016/j.orcp.2014.09.003. View

Carter S, Hill A, Mead L, Wong H, Yandell C, Buckley J . Almonds vs. carbohydrate snacks in an energy-restricted diet: Weight and cardiometabolic outcomes from a randomized trial. Obesity (Silver Spring). 2023; 31(10):2467-2481. DOI: 10.1002/oby.23860. View

Lin J, Thompson T, Cheng Y, Zhuo X, Zhang P, Gregg E . Projection of the future diabetes burden in the United States through 2060. Popul Health Metr. 2018; 16(1):9. PMC: 6003101. DOI: 10.1186/s12963-018-0166-4. View

Handelman G, MACHLIN L, Fitch K, Weiter J, Dratz E . Oral alpha-tocopherol supplements decrease plasma gamma-tocopherol levels in humans. J Nutr. 1985; 115(6):807-13. DOI: 10.1093/jn/115.6.807. View

Weiss E, Racette S, Villareal D, Fontana L, Steger-May K, Schechtman K . Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: a randomized controlled trial. Am J Clin Nutr. 2006; 84(5):1033-42. PMC: 1941677. DOI: 10.1093/ajcn/84.5.1033. View

Jiang Q, Jiang Z, Hall Y, Jang Y, Snyder P, Bain C . Gamma-tocopherol attenuates moderate but not severe colitis and suppresses moderate colitis-promoted colon tumorigenesis in mice. Free Radic Biol Med. 2013; 65:1069-1077. PMC: 3859799. DOI: 10.1016/j.freeradbiomed.2013.08.187. View

Mehta A, Singh S, Saeed A, Mahtta D, Bittner V, Sperling L . Pathophysiological Mechanisms Underlying Excess Risk for Diabetes and Cardiovascular Disease in South Asians: The Perfect Storm. Curr Diabetes Rev. 2020; 17(9):e070320183447. DOI: 10.2174/1573399816666200703182458. View

Fulgoni 3rd V, Keast D, Bailey R, Dwyer J . Foods, fortificants, and supplements: Where do Americans get their nutrients?. J Nutr. 2011; 141(10):1847-54. PMC: 3174857. DOI: 10.3945/jn.111.142257. View

10.

Jung H, Chen C, Blumberg J, Kwak H . The effect of almonds on vitamin E status and cardiovascular risk factors in Korean adults: a randomized clinical trial. Eur J Nutr. 2017; 57(6):2069-2079. PMC: 6105263. DOI: 10.1007/s00394-017-1480-5. View

11.

Dube J, Amati F, Toledo F, Stefanovic-Racic M, Rossi A, Coen P . Effects of weight loss and exercise on insulin resistance, and intramyocellular triacylglycerol, diacylglycerol and ceramide. Diabetologia. 2011; 54(5):1147-56. PMC: 3804898. DOI: 10.1007/s00125-011-2065-0. View

12.

Gao X, Wilde P, Lichtenstein A, Bermudez O, Tucker K . The maximal amount of dietary alpha-tocopherol intake in U.S. adults (NHANES 2001-2002). J Nutr. 2006; 136(4):1021-6. DOI: 10.1093/jn/136.4.1021. View

13.

McCrory M, Hajduk C, Roberts S . Procedures for screening out inaccurate reports of dietary energy intake. Public Health Nutr. 2003; 5(6A):873-82. DOI: 10.1079/PHN2002387. View

14.

Tey S, Brown R, Chisholm A, Gray A, Williams S, Delahunty C . Current guidelines for nut consumption are achievable and sustainable: a hazelnut intervention. Br J Nutr. 2011; 105(10):1503-11. DOI: 10.1017/S0007114510005283. View

15.

Liu K, Nakatsu C, Jones-Hall Y, Kozik A, Jiang Q . Vitamin E alpha- and gamma-tocopherol mitigate colitis, protect intestinal barrier function and modulate the gut microbiota in mice. Free Radic Biol Med. 2020; 163:180-189. DOI: 10.1016/j.freeradbiomed.2020.12.017. View

16.

Jenkins D, Kendall C, Josse A, Salvatore S, Brighenti F, Augustin L . Almonds decrease postprandial glycemia, insulinemia, and oxidative damage in healthy individuals. J Nutr. 2006; 136(12):2987-92. DOI: 10.1093/jn/136.12.2987. View

17.

Ren M, Zhang H, Qi J, Hu A, Jiang Q, Hou Y . An Almond-Based Low Carbohydrate Diet Improves Depression and Glycometabolism in Patients with Type 2 Diabetes through Modulating Gut Microbiota and GLP-1: A Randomized Controlled Trial. Nutrients. 2020; 12(10). PMC: 7601479. DOI: 10.3390/nu12103036. View

18.

Nikodijevic C, Probst Y, Tan S, Neale E . The Effects of Tree Nut and Peanut Consumption on Energy Compensation and Energy Expenditure: A Systematic Review and Meta-Analysis. Adv Nutr. 2023; 14(1):77-98. PMC: 10102987. DOI: 10.1016/j.advnut.2022.10.006. View

19.

Bowen J, Luscombe-Marsh N, Stonehouse W, Tran C, Rogers G, Johnson N . Effects of almond consumption on metabolic function and liver fat in overweight and obese adults with elevated fasting blood glucose: A randomised controlled trial. Clin Nutr ESPEN. 2019; 30:10-18. DOI: 10.1016/j.clnesp.2018.12.088. View

20.

Cohen A, Johnston C . Almond ingestion at mealtime reduces postprandial glycemia and chronic ingestion reduces hemoglobin A(1c) in individuals with well-controlled type 2 diabetes mellitus. Metabolism. 2011; 60(9):1312-7. DOI: 10.1016/j.metabol.2011.01.017. View