RettDb: the Rett Syndrome Omics Database to Navigate the Rett Syndrome Genomic Landscape

Overview

Journal Database (Oxford)

Specialty Biology

Date 2024 Oct 16

PMID 39414258

Authors

Nico Cillari

Giuseppe Neri

Nadia Pisanti

Paolo Milazzo

Ugo Borello

Affiliations

Soon will be listed here.

Abstract

Rett syndrome (RTT) is a neurodevelopmental disorder occurring almost exclusively in females and leading to a variety of impairments and disabilities from mild to severe. In >95% cases, RTT is due to mutations in the X-linked gene MECP2, but the molecular mechanisms determining RTT are unknown at present, and the complexity of the system is challenging. To facilitate and provide guidance to the unraveling of those mechanisms, we developed a database resource for the visualization and analysis of the genomic landscape in the context of wild-type or mutated Mecp2 gene in the mouse model. Our resource allows for the exploration of differential dynamics of gene expression and the prediction of new potential MECP2 target genes to decipher the RTT disorder molecular mechanisms. Database URL: https://biomedinfo.di.unipi.it/rett-database/.

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