Bioinformatic Resources for Exploring Human-virus Protein-protein Interactions Based on Binding Modes

Overview

Journal Genomics Proteomics Bioinformatics

Specialty Biology

Date 2024 Oct 15

PMID 39404802

Authors

Huimin Chen

Jiaxin Liu

Gege Tang

Gefei Hao

Guangfu Yang

Affiliations

Soon will be listed here.

Abstract

Historically, there have been many outbreaks of viral diseases that have continued to claim millions of lives. Research on human-virus protein-protein interactions (PPIs) is vital to understanding the principles of human-virus relationships, providing an essential foundation for developing virus control strategies to combat diseases. The rapidly accumulating data on human-virus PPIs offer unprecedented opportunities for bioinformatics research around human-virus PPIs. However, available detailed analyses and summaries to help use these resources systematically and efficiently are lacking. Here, we comprehensively review the bioinformatic resources used in human-virus PPI research, and discuss and compare their functions, performance, and limitations. This review aims to provide researchers with a bioinformatic toolbox that will hopefully better facilitate the exploration of human-virus PPIs based on binding modes.

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