Is ABO Blood Type a Risk Factor for Adjacent Segment Degeneration After Lumbar Spine Fusion?

Overview

Journal Eur Spine J

Specialty Orthopedics

Date 2024 Oct 14

PMID 39402430

Authors

Samuel S Rudisill

Dustin H Massel

Alexander L Hornung

Cameron Kia

Karan Patel

Khaled Aboushaala

Mbagwu Chukwuemeka

Arnold Y L Wong

J Nicolas Barajas

G Michael Mallow

Sheila J Toro

Harmanjeet Singh

Rahul Gawri

Philip K Louie

Frank M Phillips

Howard S An

Dino Samartzis

Affiliations

Soon will be listed here.

Abstract

Purpose: This study aimed to explore associations between ABO blood type and postoperative adjacent segment degeneration/disease (ASD) following lumbar spine fusion, as well as evaluate differences in spinopelvic alignment, perioperative care, postoperative complications, and patient-reported outcome measures (PROMs).

Methods: An ambispective study was performed. Patients who underwent posterolateral or posterior lumbar interbody fusion were included. Demographic, perioperative and postoperative, clinical, and blood type information was recorded. Pre- and post-operative radiographic imaging was analyzed for alignment parameters and development of ASD.

Results: 445 patients were included, representing O+ (36.0%), O- (5.2%), A+ (36.2%), A- (6.3%), B+ (12.1%), B- (1.6%), and AB+ (2.7%) blood types. Most patients were female (59.1%), and had a mean age of 60.3 years and BMI of 31.1 kg/m. Postoperatively, groups did not differ in duration of the hospital (p = 0.732) or intensive care unit (p = 0.830) stay, discharge disposition (p = 0.504), reoperation rate (p = 0.192), or in-hospital complication rate (p = 0.377). Postoperative epidural hematoma was most common amongst A + patients (p = 0.024). Over a mean of 11.0 months of follow-up, all patients exhibited similar improvement in PROMs, with 132 (29.7%) patients developing radiographic evidence of ASD. B + patients were significantly more likely than A + and O + patients to develop spondylolisthesis and ASD (p < 0.05). No significant differences in sagittal alignment parameters and number of levels of fusion were found (p > 0.05).

Conclusions: This is the first large-scale study to address and demonstrate proof-of-principle that ABO blood type, a non-modifiable risk factor, is associated with ASD following lumbar spine fusion.

Citing Articles

Letter to the editor concerning "Is ABO blood type a risk factor for adjacent segment degeneration after lumbar Spine Fusion?" By S.S. Rudisill, et al. (Eur Spine J [2024]: doi: 10.1007/s00586-024-08516-y).

Wang Y, Guan W Eur Spine J. 2024; .

PMID: 39663227 DOI: 10.1007/s00586-024-08608-9.

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