Spatial Multiomics Reveals Intratumoral Immune Heterogeneity with Distinct Cytokine Networks in Lung Cancer Brain Metastases

Overview

Journal Cancer Res Commun

Specialty Oncology

Date 2024 Oct 14

PMID 39400127

Authors

Gustav Christensson

Matteo Bocci

Julhash U Kazi

Geoffroy Durand

Gustav Lanzing

Kristian Pietras

Hugo Gonzalez Velozo

Catharina Hagerling

Affiliations

Soon will be listed here.

Abstract

Significance: Immune cell signatures are conserved across lung cancer brain metastases, and immune-metastatic tumor cell networks have a prognostic effect, implying that targeting cytokine networks between immune and metastatic tumor cells may generate more precise immunotherapeutic approaches.

Citing Articles

Molecular Underpinnings of Brain Metastases.

Jacome M, Wu Q, Chen J, Mohamed Z, Mokhtari S, Pina Y Int J Mol Sci. 2025; 26(5).

PMID: 40076927 PMC: 11900073. DOI: 10.3390/ijms26052307.

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