Efficacy of Picosecond Laser in Clinical, Histopathology, and Immunohistochemistry Examination in Indonesian Wrinkled Skin

Overview

Journal J Lasers Med Sci

Date 2024 Oct 9

PMID 39381786

Authors

Putri Hendria Wardhani

Cita Rosita Sigit Prakoeswa

Muhammad Yulianto Listiawan

Affiliations

Soon will be listed here.

Abstract

The elderly population wants to improve skin function and maintain a youthful appearance without wrinkles. Laser is one of the highly developed and widely used therapeutic modalities of skin aging by stimulating dermal collagen formation. Picosecond laser therapy is performed on skin with wrinkles to determine the mechanism of wrinkle improvement with a picosecond laser through an increasing in tissue inhibitor of metalloproteinases 1 (TIMP-1), and a decrease in matrix metalloproteinase-1 (MMP-1), which was confirmed by collagen density. The study was started from March 2021 to July 2021 at URJ Dr. Soetomo Hospital Surabaya and Surabaya Skin Centre. Twenty patients meeting the inclusion criteria of being 36-55 years of age and having a wrinkle in the forearm were enrolled by random sampling. Each sample data was recorded, the average TIMP-1, MMP-1, collagen density, and clinical wrinkles were calculated, and the laser was performed by using a picosecond 755 nm laser. All patients showed a moderate pre-test wrinkle scale. The figure for TIMP-1 and MMP-1 after therapy was higher. The MMP-1/TIMP-1 ratio in wrinkles treated by using a picosecond laser was lower but insignificant than before. The picture of collagen density indicates that collagen density after laser therapy was higher than before. The result of clinical examination, histopathology, and immunohistochemistry in this research explained that a picosecond 755 nm laser with DLA is an effective therapy for wrinkles in Indonesian patients without any adverse effects.

References

Ye X, Wang L, Dang Y, Liu B, Zhao D . Investigation of the 1064 nm Q-switched Nd:YAG laser on collagen expression in an animal model. Photomed Laser Surg. 2012; 30(10):604-9. DOI: 10.1089/pho.2012.3221. View

Natari S, Kim K, Ryu S, Park J, Kim I . Device-Induced Neocollagenesis: Profibrotic Response or True Neocollagenesis?. Lasers Surg Med. 2020; 52(10):1010-1019. DOI: 10.1002/lsm.23258. View

Manriquez J, Cataldo K, Vera-Kellet C, Harz-Fresno I . Wrinkles. BMJ Clin Evid. 2015; 2014. PMC: 4278179. View

Shin J, Kwon S, Choi J, Na J, Huh C, Choi H . Molecular Mechanisms of Dermal Aging and Antiaging Approaches. Int J Mol Sci. 2019; 20(9). PMC: 6540032. DOI: 10.3390/ijms20092126. View

Oktem A, Kocyigit P . Comparison of effectiveness of 1,064-nm Nd:YAG laser and Nd:YAG laser-IPL combination treatments in hand skin rejuvenation. J Cosmet Laser Ther. 2016; 18(5):270-4. DOI: 10.3109/14764172.2016.1157366. View

Tanghetti E, Tartar D . Comparison of the Cutaneous Thermal Signatures Over Twenty-Four Hours With a Picosecond Alexandrite Laser Using a Flat or Fractional Optic. J Drugs Dermatol. 2017; 15(11):1347-1352. View

Wu D, Goldman M, Wat H, Chan H . A Systematic Review of Picosecond Laser in Dermatology: Evidence and Recommendations. Lasers Surg Med. 2020; 53(1):9-49. DOI: 10.1002/lsm.23244. View

Weiss R, McDaniel D, Weiss M, Mahoney A, Beasley K, Halvorson C . Safety and efficacy of a novel diffractive lens array using a picosecond 755 nm alexandrite laser for treatment of wrinkles. Lasers Surg Med. 2016; 49(1):40-44. PMC: 5297872. DOI: 10.1002/lsm.22577. View

Yang Z, Duan X, Wang X, Xu Q, Guo B, Xiang S . The effect of Q-switched 1064-nm Nd: YAG laser on skin barrier and collagen synthesis via miR-663a to regulate TGFβ1/smad3/p38MAPK pathway. Photodermatol Photoimmunol Photomed. 2021; 37(5):412-421. DOI: 10.1111/phpp.12673. View

10.

Haimovic A, Brauer J, Bae Y, Geronemus R . Safety of a picosecond laser with diffractive lens array (DLA) in the treatment of Fitzpatrick skin types IV to VI: A retrospective review. J Am Acad Dermatol. 2016; 74(5):931-6. DOI: 10.1016/j.jaad.2015.12.010. View

11.

Humbert P, Viennet C, Legagneux K, Grandmottet F, Robin S, Oddos T . In the shadow of the wrinkle: theories. J Cosmet Dermatol. 2012; 11(1):72-8. DOI: 10.1111/j.1473-2165.2011.00602.x. View

12.

Yang Z, Xiang H, Duan X, Liu J, He X, He Y . Q-switched 1064-nm dymium-doped yttrium aluminum garnet laser irradiation induces skin collagen synthesis by stimulating MAPKs pathway. Lasers Med Sci. 2018; 34(5):963-971. DOI: 10.1007/s10103-018-2683-6. View

13.

Farage M, Miller K, Elsner P, Maibach H . Characteristics of the Aging Skin. Adv Wound Care (New Rochelle). 2014; 2(1):5-10. PMC: 3840548. DOI: 10.1089/wound.2011.0356. View

14.

Anson G, Kane M, Lambros V . Sleep Wrinkles: Facial Aging and Facial Distortion During Sleep. Aesthet Surg J. 2016; 36(8):931-40. DOI: 10.1093/asj/sjw074. View

15.

Tanghetti E . The histology of skin treated with a picosecond alexandrite laser and a fractional lens array. Lasers Surg Med. 2016; 48(7):646-52. DOI: 10.1002/lsm.22540. View

16.

Rhee D, Cho H, Park G, Moon H, Chang S, Won C . Histological and molecular analysis of the long-pulse 1,064-nm Nd:YAG laser irradiation on the ultraviolet-damaged skin of hairless mice: In association with pulse duration change. J Cosmet Laser Ther. 2015; 18(1):16-21. DOI: 10.3109/14764172.2015.1052509. View

17.

Saluja S, Fabi S . A Holistic Approach to Antiaging as an Adjunct to Antiaging Procedures: A Review of the Literature. Dermatol Surg. 2017; 43(4):475-484. DOI: 10.1097/DSS.0000000000001027. View

18.

Dang Y, Ye X, Weng Y, Tong Z, Ren Q . Effects of the 532-nm and 1,064-nm Q-switched Nd:YAG lasers on collagen turnover of cultured human skin fibroblasts: a comparative study. Lasers Med Sci. 2010; 25(5):719-26. DOI: 10.1007/s10103-009-0657-4. View

19.

De Filippis A, Perfetto B, Guerrera L, Oliviero G, Baroni A . Q-switched 1064 nm Nd-Yag nanosecond laser effects on skin barrier function and on molecular rejuvenation markers in keratinocyte-fibroblasts interaction. Lasers Med Sci. 2018; 34(3):595-605. DOI: 10.1007/s10103-018-2635-1. View