Flaviviruses Manipulate Mitochondrial Processes to Evade the Innate Immune Response

Overview

Journal Npj Viruses

Date 2024 Oct 7

PMID 39371935

Authors

RuthMabel Boytz

Kadiatou Keita

Joanna B Pawlak

Maudry Laurent-Rolle

Affiliations

Soon will be listed here.

Abstract

Mitochondria are essential eukaryotic organelles that regulate a range of cellular processes, from metabolism to calcium homeostasis and programmed cell death. They serve as essential platforms for antiviral signaling proteins during the innate immune response to viral infections. Mitochondria are dynamic structures, undergoing frequent fusion and fission processes that regulate various aspects of mitochondrial biology, including innate immunity. Pathogens have evolved sophisticated mechanisms to manipulate mitochondrial morphology and function to facilitate their replication. In this review, we examine the emerging literature on how flaviviruses modulate mitochondrial processes.

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