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Exosomes Are the Mediators Between the Tumor Microenvironment and Prostate Cancer (Review)

Overview
Journal Exp Ther Med
Specialty Pathology
Date 2024 Oct 2
PMID 39355518
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Abstract

Prostate cancer poses a serious threat to the well-being of men worldwide, with the leading cause of mortality being primarily through metastasis. Prostate cancer metastasis is dependent on cell communication, which is an essential component of this process; yet its exact mechanism remains obscure. Nonetheless, cell-to-cell communication plays a critical part in prostate cancer metastasis. Exosomes play an indispensable role in the development of metastatic growth by promoting intercellular communication. They are pivotal regulatory agents for both prostate cancer cells as well as their microenvironment. The present study investigated the makeup and function of exosomes in the tumor microenvironment, highlighting their significance to prostate cancer metastasis.

References
1.
Wroblewska J, Lach M, Kulcenty K, Galus L, Suchorska W, Rosel D . The Analysis of Inflammation-Related Proteins in a Cargo of Exosomes Derived from the Serum of Uveal Melanoma Patients Reveals Potential Biomarkers of Disease Progression. Cancers (Basel). 2021; 13(13). PMC: 8268237. DOI: 10.3390/cancers13133334. View

2.
Che Y, Shi X, Shi Y, Jiang X, Ai Q, Shi Y . Exosomes Derived from miR-143-Overexpressing MSCs Inhibit Cell Migration and Invasion in Human Prostate Cancer by Downregulating TFF3. Mol Ther Nucleic Acids. 2019; 18:232-244. PMC: 6796755. DOI: 10.1016/j.omtn.2019.08.010. View

3.
. Exosomes. Nat Biotechnol. 2020; 38(10):1150. DOI: 10.1038/s41587-020-0696-8. View

4.
Shikanai M, Yuzaki M, Kawauchi T . Rab family small GTPases-mediated regulation of intracellular logistics in neural development. Histol Histopathol. 2017; 33(8):765-771. DOI: 10.14670/HH-11-956. View

5.
Karlsson T, Lundholm M, Widmark A, Persson E . Tumor Cell-Derived Exosomes from the Prostate Cancer Cell Line TRAMP-C1 Impair Osteoclast Formation and Differentiation. PLoS One. 2016; 11(11):e0166284. PMC: 5104397. DOI: 10.1371/journal.pone.0166284. View