The Emergence of Clonal Hematopoiesis As a Disease Determinant

Overview

Journal J Clin Invest

Specialty General Medicine

Date 2024 Oct 1

PMID 39352387

Authors

Kenneth Walsh

Affiliations

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Citing Articles

Deciphering the Complexities of Adult Human Steady State and Stress-Induced Hematopoiesis: Progress and Challenges.

Watt S, Roubelakis M Int J Mol Sci. 2025; 26(2).

PMID: 39859383 PMC: 11766050. DOI: 10.3390/ijms26020671.

References

Nachun D, Lu A, Bick A, Natarajan P, Weinstock J, Szeto M . Clonal hematopoiesis associated with epigenetic aging and clinical outcomes. Aging Cell. 2021; 20(6):e13366. PMC: 8208788. DOI: 10.1111/acel.13366. View

Schleicher W, Hoag B, De Dominici M, DeGregori J, Pietras E . CHIP: a clonal odyssey of the bone marrow niche. J Clin Invest. 2024; 134(15). PMC: 11290965. DOI: 10.1172/JCI180068. View

Genovese G, Kahler A, Handsaker R, Lindberg J, Rose S, Bakhoum S . Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence. N Engl J Med. 2014; 371(26):2477-87. PMC: 4290021. DOI: 10.1056/NEJMoa1409405. View

Oren O, Small A, Libby P . Clonal hematopoiesis and atherosclerosis. J Clin Invest. 2024; 134(19). PMC: 11444192. DOI: 10.1172/JCI180066. View

Young A, Challen G, Birmann B, Druley T . Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults. Nat Commun. 2016; 7:12484. PMC: 4996934. DOI: 10.1038/ncomms12484. View

Busque L, Mio R, Mattioli J, Brais E, Blais N, Lalonde Y . Nonrandom X-inactivation patterns in normal females: lyonization ratios vary with age. Blood. 1996; 88(1):59-65. View

Takahashi K, Nakada D, Goodell M . Distinct landscape and clinical implications of therapy-related clonal hematopoiesis. J Clin Invest. 2024; 134(19). PMC: 11444158. DOI: 10.1172/JCI180069. View

Sano S, Horitani K, Ogawa H, Halvardson J, Chavkin N, Wang Y . Hematopoietic loss of Y chromosome leads to cardiac fibrosis and heart failure mortality. Science. 2022; 377(6603):292-297. PMC: 9437978. DOI: 10.1126/science.abn3100. View

Mitchell E, Spencer Chapman M, Williams N, Dawson K, Mende N, Calderbank E . Clonal dynamics of haematopoiesis across the human lifespan. Nature. 2022; 606(7913):343-350. PMC: 9177428. DOI: 10.1038/s41586-022-04786-y. View

10.

Poon G, Watson C, Fisher D, Blundell J . Synonymous mutations reveal genome-wide levels of positive selection in healthy tissues. Nat Genet. 2021; 53(11):1597-1605. DOI: 10.1038/s41588-021-00957-1. View

11.

Evans M, Sano S, Walsh K . Clonal haematopoiesis and cardiovascular disease: how low can you go?. Eur Heart J. 2020; 42(3):266-268. DOI: 10.1093/eurheartj/ehaa848. View

12.

Evans M, Walsh K . Clonal hematopoiesis, somatic mosaicism, and age-associated disease. Physiol Rev. 2022; 103(1):649-716. PMC: 9639777. DOI: 10.1152/physrev.00004.2022. View

13.

Fuster J, MacLauchlan S, Zuriaga M, Polackal M, Ostriker A, Chakraborty R . Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice. Science. 2017; 355(6327):842-847. PMC: 5542057. DOI: 10.1126/science.aag1381. View

14.

Beeler J, Bolton K . How low can you go?: Methodologic considerations in clonal hematopoiesis variant calling. Leuk Res. 2023; 135:107419. DOI: 10.1016/j.leukres.2023.107419. View

15.

Yura Y, Cochran J, Walsh K . Therapy-Related Clonal Hematopoiesis: A New Link Between Cancer and Cardiovascular Disease. Heart Fail Clin. 2022; 18(3):349-359. PMC: 9219036. DOI: 10.1016/j.hfc.2022.02.010. View

16.

Sano S, Oshima K, Wang Y, MacLauchlan S, Katanasaka Y, Sano M . Tet2-Mediated Clonal Hematopoiesis Accelerates Heart Failure Through a Mechanism Involving the IL-1β/NLRP3 Inflammasome. J Am Coll Cardiol. 2018; 71(8):875-886. PMC: 5828038. DOI: 10.1016/j.jacc.2017.12.037. View

17.

Wang Y, Sano S, Ogawa H, Horitani K, Evans M, Yura Y . Murine models of clonal haematopoiesis to assess mechanisms of cardiovascular disease. Cardiovasc Res. 2021; 118(6):1413-1432. PMC: 9075001. DOI: 10.1093/cvr/cvab215. View

18.

Busque L, Patel J, Figueroa M, Vasanthakumar A, Provost S, Hamilou Z . Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis. Nat Genet. 2012; 44(11):1179-81. PMC: 3483435. DOI: 10.1038/ng.2413. View

19.

Zink F, Stacey S, Norddahl G, Frigge M, Magnusson O, Jonsdottir I . Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly. Blood. 2017; 130(6):742-752. PMC: 5553576. DOI: 10.1182/blood-2017-02-769869. View

20.

Dunn W, McLoughlin M, Vassiliou G . Clonal hematopoiesis and hematological malignancy. J Clin Invest. 2024; 134(19). PMC: 11444162. DOI: 10.1172/JCI180065. View