Advances in Nucleic Acid Aptamer-based Detection of Respiratory Virus and Bacteria: a Mini Review

Overview

Journal Virol J

Publisher Biomed Central

Specialty Microbiology

Date 2024 Oct 1

PMID 39350296

Authors

Rui-Min Feng

Ye Liu

Zhi-Qiang Liu

Li Wang

Nan Chen

Yu Zhao

Hua-Wei Yi

Affiliations

Soon will be listed here.

Abstract

Respiratory pathogens infecting the human respiratory system are characterized by their diversity, high infectivity, rapid transmission, and acute onset. Traditional detection methods are time-consuming, have low sensitivity, and lack specificity, failing to meet the needs of rapid clinical diagnosis. Nucleic acid aptamers, as an emerging and innovative detection technology, offer novel solutions with high specificity, affinity, and broad target applicability, making them particularly promising for respiratory pathogen detection. This review highlights the progress in the research and application of nucleic acid aptamers for detecting respiratory pathogens, discussing their selection, application, potential in clinical diagnosis, and future development. Notably, these aptamers can significantly enhance the sensitivity and specificity of detection when combined with detection techniques such as fluorescence, colorimetry and electrochemistry. This review offers new insights into how aptamers can address the limitations of traditional diagnostic methods and advance clinical diagnostics. It also highlights key challenges and future research directions for the clinical application of nucleic acid aptamers.

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