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Biocompatible Native Hyaluronan Nanofibers Fabricated Via Aqueous PEO-Assisted Electrospinning and Heat-Quench Process

Overview
Journal ACS Omega
Specialty Chemistry
Date 2024 Sep 30
PMID 39346818
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Abstract

Hyaluronan (HA) is widely used in cosmetic and biomedical applications due to its excellent biocompatibility and potential to promote wound healing. Nanofibrous HA, mimicking the extracellular matrix (ECM), is considered promising for therapeutic and cosmetic applications. However, the electrospinning process of HA often necessitates cytotoxic solvents and chemical modifications, compromising its biocompatibility and advantageous properties. In this study, poly(ethylene oxide) (PEO) was added to an aqueous solution of natural HA to improve its spinnability, enabling HA to be electrospun into fibers. The HA was rendered water-insoluble by treatment with an acidic solution, and the amorphized PEO, achieved by heat-quenching, was removed through water washing. This method distinguishes it from previous reports of fibers blended with PEO or other water-soluble polymers. Consequently, the resulting HA gel fibers demonstrated suitability for mesenchymal stem cell adhesion due to the exposure of HA on the fiber surface. Additionally, HA fibers were successfully applied directly onto the skin using a hand-held electrospinning device, indicating the potential for point-of-care and home use applications.

References
1.
Zhang K, Shi Z, Zhou J, Xing Q, Ma S, Li Q . Potential application of an injectable hydrogel scaffold loaded with mesenchymal stem cells for treating traumatic brain injury. J Mater Chem B. 2020; 6(19):2982-2992. DOI: 10.1039/c7tb03213g. View

2.
Yan X, Yu M, Ramakrishna S, Russell S, Long Y . Advances in portable electrospinning devices for in situ delivery of personalized wound care. Nanoscale. 2019; 11(41):19166-19178. DOI: 10.1039/c9nr02802a. View

3.
Revia R, Wagner B, Zhang M . A Portable Electrospinner for Nanofiber Synthesis and Its Application for Cosmetic Treatment of Alopecia. Nanomaterials (Basel). 2019; 9(9). PMC: 6781269. DOI: 10.3390/nano9091317. View

4.
Yan X, Yu M, Zhang L, Jia X, Li J, Duan X . A portable electrospinning apparatus based on a small solar cell and a hand generator: design, performance and application. Nanoscale. 2015; 8(1):209-13. DOI: 10.1039/c5nr06858d. View

5.
Voigt J, Driver V . Hyaluronic acid derivatives and their healing effect on burns, epithelial surgical wounds, and chronic wounds: a systematic review and meta-analysis of randomized controlled trials. Wound Repair Regen. 2012; 20(3):317-31. DOI: 10.1111/j.1524-475X.2012.00777.x. View